Pharmaceutical composition for easing pain and use thereof

Abstract

The invention relates to a pharmaceutical composition for easing pain. The pharmaceutical composition is prepared from the following components according to the volume ratio: 2% methylthioninium chloride injection, 0.5% bupivacaine hydrochloride injection, 2% lidocaine hydrochloride injection and water for injection, of which the ratio is 2:5:5:16. The pharmaceutical composition relieves pain after being applied to an anorectal postoperative incision, improves local blood circulation, benefits for wound concrescence, contributes to wound bleeding, and reduces secreta. The pharmaceutical composition does not generate systemic adverse reaction after an operation, local edema or necrosis by a clinical test, and has no influence on local granulation tissue growth and wound concrescence; the anus has no abnormity, can smoothly defecate after the wound is repaired, has no untoward effect after follow-up treatment, and is reliable in curative effect. The drug disclosed by the invention removes a local hot pain after methylenum coeruleum is injected, does not generate an anesthesia clearance, is fast to take effect, and takes effect after being injected 2-4 hours; the reversible nerve damage disappears after about 15 days in general; and the requirement of wound growth just can be met.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an analgesic pharmaceutical composition and its application. Background technique [0002] Pain treatment emerged in the 1930s (USA), and it was officially launched in my country in the early 1980s. However, compared with foreign countries, there is still a gap in some aspects, especially the pain treatment of anorectal surgery, which lags behind other surgical specialties. In the 1980s, methylene blue was simply used for postoperative incision injection, and the pain was significantly relieved, but the local burning pain was not significantly relieved. In the 1990s, the combined administration of methylene blue + bupivacaine was used, but its onset was slow, and it took about 4-6 hours to take effect after a slow rise and fall, and there was a heat-like pain 2-4 hours after injection, so Compared with the simple use of methylene blue, there is a significant im...

AI Technical Summary

Problems solved by technology

But poor permeability, slow onset