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Solvent auxiliary electrospray ionization device and method for achieving electrospray ionization by utilizing same

A technology of electrospray and auxiliary electrospray, which is applied in the field of mass spectrometry, can solve the problems of complex operation of the device, small droplet size, interference reaction monitoring, etc., to suppress background signal interference, improve ionization efficiency, and avoid discharge phenomenon Effect

Active Publication Date: 2013-08-21
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the ionization method of EESI, in order to obtain the best signal, many parameters need to be adjusted, which complicates the operation of the device
At the same time, because the droplets are disturbed by the airflow of the atomized gas, the collision efficiency between the charged droplets and the sample droplets is reduced, which reduces the ionization efficiency to a certain extent.
In addition, since the size of the droplets ejected from the electrospray channel is smaller than that of the analyte, the matrix effect cannot be completely overcome.
Moreover, the more active intermediate species in the organic reaction solution may have unwanted molecular ion reactions when they collide with the charged droplets, interfering with the monitoring of the reaction

Method used

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  • Solvent auxiliary electrospray ionization device and method for achieving electrospray ionization by utilizing same
  • Solvent auxiliary electrospray ionization device and method for achieving electrospray ionization by utilizing same
  • Solvent auxiliary electrospray ionization device and method for achieving electrospray ionization by utilizing same

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Embodiment 1

[0040] For gold catalyst (Ph 3 wxya 2 ) The cyclization reaction solution of the catalytic substrate 1 is subjected to mass spectrometry analysis: the ion source of the mass spectrometer is a solvent-assisted electrospray ionization device provided by the present invention (such as figure 1 As shown, the tip of the electrospray channel 1 is in contact with the tip of the sample introduction channel 2, and the sample introduction channel 2 has the same voltage as the electrospray channel 1; the axis of the electrospray channel 1 and the axis of the sample introduction channel 2 The included angle α is 30 to 75 degrees, and the included angle β with the axis of the mass spectrometry sampling channel 3 is 120 degrees; the axis of the sample introduction channel 2 and the axis of the mass spectrometry sampling channel 3 are on the same horizontal line, and the sample introduction channel The distance d between the port of 2 and the port of mass spectrometry sampling channel 3 is ...

Embodiment 2

[0046] For gold catalyst (Ph 3 wxya 2 ) The cyclization reaction solution of the catalytic substrate 2 is subjected to mass spectrometry analysis: the ion source of the mass spectrometer is a solvent-assisted electrospray ionization device provided by the present invention (such as figure 1 As shown, the tip of the electrospray channel 1 is in contact with the tip of the sample introduction channel 2, and the sample introduction channel 2 has the same voltage as the electrospray channel 1; the axis of the electrospray channel 1 and the axis of the sample introduction channel 2 The included angle α is 30 to 75 degrees, and the included angle β with the axis of the mass spectrometry sampling channel 3 is 120 degrees; the axis of the sample introduction channel 2 and the axis of the mass spectrometry sampling channel 3 are on the same horizontal line, and the sample introduction channel The distance d between the port of 2 and the port of mass spectrometry sampling channel 3 is ...

Embodiment 3

[0052] For gold catalyst (Ph 3 wxya 2 ) The cyclization reaction solution of the catalytic substrate 3 is subjected to mass spectrometry analysis: the ion source of the mass spectrometer is a solvent-assisted electrospray ionization device provided by the present invention (such as figure 1 As shown, the tip of the electrospray channel 1 is in contact with the tip of the sample introduction channel 2, and the sample introduction channel 2 has the same voltage as the electrospray channel 1; the axis of the electrospray channel 1 and the axis of the sample introduction channel 2 The included angle α is 30 to 75 degrees, and the included angle β with the axis of the mass spectrometry sampling channel 3 is 120 degrees; the axis of the sample introduction channel 2 and the axis of the mass spectrometry sampling channel 3 are on the same horizontal line, and the sample introduction channel The distance d between the port of 2 and the port of mass spectrometry sampling channel 3 is ...

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Abstract

The invention discloses a solvent auxiliary electrospray ionization device and a method for achieving electrospray ionization by utilizing the same. The device comprises an electrospray channel and a sample leading-in channel, an included angle between the axis of the electrospray channel and the axis of the sample leading-in channel is an acute angle, an included angle between the axis of the electrospray channel and the axis of the mass spectrum sample feeding channel is an acute angle, the axis of the electrospray channel, the axis of the sample leading-in channel and the axis of the mass spectrum sample feeding channel are intersected in the same plane, and the tip end of the electrospray channel is contacted with the tip end of the sample leading-in channel. The method for achieving electrospray ionization by utilizing the device comprises the steps of enabling auxiliary solvent to flow into the electrospray channel; enabling solution of a sample to be tested to be lead into the electrospray channel; when the auxiliary solvent is mixed with the solution of the sample to be tested, removing the solvent through electrospray. The solvent auxiliary electrospray ionization device and the method for achieving electrospray ionization by utilizing the solvent auxiliary electrospray ionization device not only can be applied to mass spectrometry of chemical reactions in electrospray-unfriendly solvent, but also can be compatible with commonly used mass spectrometers, and is strong in practicality.

Description

technical field [0001] The invention relates to a solvent-assisted electrospray ionization device and a method for using the device to realize electrospray ionization, belonging to the technical field of mass spectrometry. Background technique [0002] Electrospray ionization (ESI), since its introduction in the 1970s, has become the most widely used ionization method in the field of mass spectrometry because of its soft ionization characteristics that are not prone to fragmentation. In the 1990s, Stephen R. Wilson's group successfully applied electrospray mass spectrometry to the detection and characterization of organic chemical reaction (wittig reaction) intermediates. Electrospray ionization mass spectrometry (ESI-MS) has been used in the study of poorly stable reaction intermediates, metal complexes, and organic reaction catalysis due to its ability to specifically capture ionic species and maintain their integrity. However, for some organic reactions, the reactants ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/04H01J49/16H01J49/26
Inventor 郭寅龙张骏婷王昊阳张立张菁
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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