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Salts of buxus microphylla base derivative

A technology of xanthophylline and compound, which is applied in the field of xanthophylline organic acid salt and its pharmaceutical application, can solve the problems of adverse reactions, unsatisfactory therapeutic effect, drug resistance and the like, and achieves the effect of practical therapeutic activity

Inactive Publication Date: 2013-09-11
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs for the treatment of cancer, these existing drugs are likely to cause multiple and severe adverse reactions, and some produce drug resistance, and the therapeutic effect of the existing drugs is still not ideal.

Method used

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  • Salts of buxus microphylla base derivative
  • Salts of buxus microphylla base derivative
  • Salts of buxus microphylla base derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Xanthine fumarate

[0048] 5.95 g (0.01 mol) of the compound phylloxanthine and 1.17 g (0.01 mol) of fumaric acid were dissolved in 140 ml of boiling ethanol. This hot solution was filtered through diatomaceous earth, then slowly cooled under gentle stirring, and allowed to stand for several hours in a temperature environment of 0-5°C to precipitate the xanthine fumarate crystals and filter out xanthine fumarate. The acid salt crystals were washed with ethanol and dried under vacuum at 50°C to obtain 7.10 g of product.

Embodiment 2

[0050] Xanthine fumarate

[0051] The compound lobular xanthine fumarate 5.95 g and 1.17 g fumaric acid were stirred in 140 ml refluxing ethanol until all the solids were dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool to room temperature while stirring. Let it stand for several hours in a temperature environment of 0-5°C to precipitate the lobular xanthine fumarate crystals, filter out the lobular xanthine fumarate crystals, wash with ethanol and dry under vacuum at 50°C to obtain 7.01 grams of product.

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Abstract

The invention relates to fumarates or pharmaceutically acceptable solvates of buxus microphylla base and derivatives, and an application for the same in preparation for a medicine treating cancers.

Description

Invention field [0001] The present invention relates to the field of medicinal chemistry. Specifically, the present invention relates to the organic acid salt of buxidin and its pharmaceutical application. Background technique [0002] At present, although there are many kinds of drugs for the treatment of cancer, the existing drugs are prone to cause many and serious adverse reactions, and some produce drug resistance, and the therapeutic effects of the existing drugs are still not ideal. The patent application with the Chinese Invention Patent Authorization Announcement No. CN101328200B describes some compounds with active cancer treatment. Summary of the invention [0003] The present invention discloses certain new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds, and pharmaceutical applications of these compounds and compositions. [0004] These compounds show good water solubility stability and solid form stability. So...

Claims

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Application Information

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IPC IPC(8): C07J53/00A61K31/57A61P35/00
Inventor 不公告发明人
Owner SHANGHAI YIZHI MEDICAL TECH
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