Preparation method of anti-osteoporosis bone implant micro/nano biomimetic coating

An anti-osteoporosis and implant technology, applied in coating, metal material coating process, ion implantation plating, etc., can solve the problems of insufficient bonding strength, high exfoliation rate, no anti-osteoporosis, etc., and achieve deposition The effect of fast speed, high bonding strength and stable performance

Active Publication Date: 2016-08-10
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

However, at present, the bonding strength between the micro / nano-coating and the metal substrate is insufficient, the exfoliation rate is high, and there is no anti-osteoporosis effect, which greatly limits its clinical application.

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  • Preparation method of anti-osteoporosis bone implant micro/nano biomimetic coating
  • Preparation method of anti-osteoporosis bone implant micro/nano biomimetic coating

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Embodiment Construction

[0018] The present invention adopts the magnetron sputtering method to prepare the surface treatment process of strontium-loaded anti-osteoporosis micro / nano biomimetic coating with high binding strength on the surface of the implant, comprising the following steps:

[0019] A. Decontaminate the surface of the implant;

[0020] B. The surface of the implant is acid-etched with a hydrofluoric acid solution with a concentration of 2%, so that micron pits of 2-5 μm are formed on the surface of the implant;

[0021] C. Then rinse the acid-etched bone implants in sequence with distilled water - ultrasonic cleaning with acetone - ultrasonic cleaning with absolute ethanol - ultrasonic cleaning with distilled water;

[0022] D. Using strontium titanate as the target material, the acid-etched bone implant as the substrate, and using radio frequency magnetron sputtering technology to prepare high bonding strength, strontium-loaded anti-osteoporosis effect on the surface of the implant s...

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Abstract

The invention discloses a preparation method of an anti-osteoporotic and high-bonding-strength micro / nano biomimetic coating of a bone implant. The method comprises: (1) putting the implant into a hydrofluoric acid solution for acid etching; and (2) putting the implant after the acid etching as a matrix into a magnetron sputtering sample introduction chamber, putting anti-osteoporotic strontium salt used as a target material into a main sputtering chamber, vacuumizing the main sputtering chamber and the sample introduction chamber, pre-sputtering the matrix for 20 minutes in the sample introduction chamber, sending the implant matrix into the main sputtering chamber, sputtering for 2-4 hours, taking out the samples from the main sputtering chamber, and performing post-treatment in a heat treatment furnace, with a post-treatment temperature being 300-500 DEG C and an insulation time being 2-4 hours. The coating provided by the invention has characteristics of high adhesion strength with the matrix, osteoporosis resistance, micro / nano biomimetic structure.

Description

technical field [0001] The invention belongs to plastic surgery, orthopedics and stomatology. The invention relates to a surface treatment method of an oral implant, in particular to a method for preparing a high bonding strength anti-osteoporosis biomimetic coating based on a magnetron sputtering method. Background technique [0002] Osteoporosis (OP) is a kind of bone metabolic disease that seriously affects human health, mainly manifested as osteopenia and degenerative changes of bone microstructure. Clinically, bone degenerative changes caused by osteoporosis can lead to loosening and falling off of orthopedic retention screws, decreased osseointegration of orthopedic and oral and maxillofacial implants, and even implant failure. Therefore, how to improve the osseointegration effect of bone implants under the condition of osteoporosis is a difficult problem that the medical community is concerned about at present. The construction of micro / nano biomimetic coatings on t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30C23C14/35C23C14/06
Inventor 孔亮李永锋高麒牛强韶波张永强沈舒宁王丽华肖剑锐李涛
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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