Non-Newtonian fluid viscosity standard substance and preparation method thereof

Abstract

The invention belongs to the field of metrology science, relates to a non-Newtonian fluid viscosity standard substance and a preparation method thereof, and particularly relates to a whole blood viscosity standard substance and a preparation method thereof. The non-Newtonian fluid viscosity standard substance provided by the invention includes, by mass: 0.1% to 3.44% of polyethylene oxide, 0.25% to 2.5% of nano SiO2 colloidal particles, and the balance being water. The non-Newtonian fluid viscosity standard substance is a typical non-Newtonian fluid having a shear-thinning characteristic at low shear rates, can better simulate whole blood fluid characteristics, and thereby being used as the whole blood viscosity standard substance; and because of interaction between the SiO2 colloidal particles and polyethylene oxide molecular chains, the non-Newton fluid viscosity standard substance has good stability and uniformity.

Description

technical field [0001] The invention belongs to the field of measurement science, and relates to a standard substance, more specifically, to a non-Newtonian fluid viscosity standard substance and a preparation method thereof, in particular to a whole blood viscosity standard substance and a preparation method thereof. Background technique [0002] Standard substances are substances with one or more sufficiently homogeneous and well-determined characteristic quantities for calibrating measuring instruments, evaluating measuring methods, or assigning values ​​to materials. As a standard substance, it must have uniformity, stability and accuracy of value. Standard substances are widely used, and can be used for ① checking and calibrating analytical instruments, ② making calibration curves, ③ quality monitoring, ④ assessing the level of laboratory technicians, and ⑤ external technical exchanges. Classification of standard substances: my country divides standard substances into ...

AI Technical Summary

Problems solved by technology

[0009] There are two types of standard substances currently used to study the viscosity curve of whole blood: one is to use Newtonian fluids so that the viscosity range can cover the viscosity values ​​of whole blood at different shear rates. This method is simple and feasible, but but imprecise

At present, the detection of whole blood viscometer in our country usually adopts the GBW13601~GBW13615 series standard viscosity liquid provided by the National Center for Standard Materials. The standard liquid is made of refined petroleum products and methyl silicone oil. The disadvantages are: (1) Petroleum products and methyl silicone oil are Newtonian fluids. It is unscientific to use a Newtonian fluid calibrated whole blood viscometer to measure non-Newtonian whole blood, which will cause great errors; (2) GBW series The standard viscosity liquid is not designed specifically for whole blood rheometers, and lacks a characteristic value similar to whole blood viscosity. It is also used for the calibration of other viscometers or rheometers; (3) The standard liquid used is very easy to Residues on the surface of the sample loading parts of the rheometer or viscometer, if not cleaned properly, will greatly pollute the subsequent measurement samples, which will bring errors to the measurement results, and the cumbersome cleaning method will bring inconvenience to the quality inspection of the whole blood rheometer

The other is to use a non-Newtonian liquid to roughly simulate the rheology of whole blood. The viscosity values ​​at different shear rates can basically correspond to the viscosity values ​​of whole blood one by one. However, due to the diversity of whole blood itself , the composition is complex, so the use of non-Newtonian fluids to simulate whole blood is still being sought and developed

At present, the non-Newtonian fluid viscosity standard substances sold on the market are all instrument companies, but these standard substances are only used for calibration and analysis of the company’s instruments, they can only be called quality control substances, and they are tested on different instruments The value deviation is very large, the uniformity and stability are quite bad, and it is far from reaching the level of promotion

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