Preparation method of lufenuron compound

A compound, lufenuron technology, applied in the field of organic synthesis, can solve the problems of complex process, low yield and the like, and achieve the effects of simple process, high yield and low cost

Inactive Publication Date: 2013-10-23
连云港埃森化学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The purpose of the present invention is to provide a new optimized synthetic method for lufenuron aimed at the shortcomings of the existing synthetic method of lufenuron, such as complex process and low yield.

Method used

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  • Preparation method of lufenuron compound
  • Preparation method of lufenuron compound
  • Preparation method of lufenuron compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] Pump 350Kg of solvent DMF into the addition kettle, start stirring, and pump in 120.0kg of baked 2,5-dichlorophenol and 65kg of 90% potassium hydroxide solution. When the temperature of the reaction kettle is controlled to 50°C, perfluoropropylene gas is started to flow. When the flow rate reaches 120kg, the content of 2,5-dichlorophenol is ≤1%, and the reaction is over. If the raw material does not disappear, continue to flow slowly, and then take a sample for analysis . After passing the test, the solvent DMF is removed under reduced pressure, and water washing and rectification are carried out to obtain the fine product IMA;

[0029] Add 150.0kg of concentrated sulfuric acid to the kettle, turn on frozen brine, slowly add 100Kg of fuming nitric acid to the kettle, and slowly add 204.0kg of IMA to the kettle at 10-15°C. During the process, the temperature in the control kettle must not exceed 20°C. After the dropwise addition, keep warm for 3 hours, take samples and...

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Abstract

The invention relates to a preparation method of a lufenuron compound. The preparation method comprises an addition reaction, a nitration reaction, a reduction reaction, an esterification reaction and a synthetic reaction. Compared with the prior art, the lufenuron product obtained by using the preparation method is high in yield, the technical process is simple and the cost is low.

Description

technical field [0001] The invention relates to a method for preparing an organic compound, in particular to a method for preparing a lufenuron compound, and belongs to the field of organic synthesis. Background technique [0002] Lufenuron is an inhibitor of insect chitin synthesis announced by Novartis in 1997, and belongs to the benzoylurea class of insecticides. The chemical name is (RS)-1-[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-3-(2,6-di Fluorobenzoyl) urea, the structural formula is: [0003] [0004] It is mainly used to prevent and control larvae of Lepidoptera such as cotton, corn, vegetables, and fruit trees; it can also be used as a sanitary drug; it can also be used to prevent and control pests in animals such as cattle. The agent kills the pests by acting on the insect larvae and stopping the peeling process, and is especially effective against leaf-eating caterpillars such as fruit trees. [0005] At present, there are two main synthetic ro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C275/54C07C273/18
Inventor 叶小光郭维成
Owner 连云港埃森化学有限公司
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