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Preparation and application of pedicellus melo tetracyclic triterpenoid cucurbitacin type compound
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A technology of cucurbitacins and tetracyclic triterpenes, which is applied in the direction of steroids, applications, food preparation, etc., can solve the few problems such as anti-aging effects, and achieve the effect of prolonging the replicative lifespan
Inactive Publication Date: 2013-10-23
ZHEJIANG UNIV +1
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But there are few reports about its anti-aging effect
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Embodiment 1
[0036] The preparation of embodiment 1 cucurbitacin mixture and cucurbitacin compounds
[0042] Embodiment 2 is to the qualitative identification of the physicochemical characteristic and chemical structure of embodiment 1 gained compound I-a-g (1-7)
[0043] The chemical structures of compounds 1-7 have been 1 H NMR, 13 C NMR, MS test, and confirmed after comparison with literature data.
[0045] Physicochemical properties of compound (2): white powder, (c 1.0, CHCl 3 ); 13 C NMR (125MHz, in CDCl 3 ): 214.0(C-22), 212.9(C-3), 21...
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Abstract
The invention provides a preparation method of a cucurbitacin type compound. The preparation method comprises the steps of extracting pedicellus melo by using an organic solvent, performing solvent distribution on an extract, and performing silica gel column separation and purification by high performance liquid chromatography on a sample after concentration to obtain a cucurbitacin mixture and a cucurbitaceae type compound. Through an anti-aging yeast model-K6001 yeastcell, an active ingredient, namely the cucurbitacin type compound is proved to be capable of significantly prolonging the replicative life span of yeast, so that the cucurbitacin mixture and the cucurbitaceae type compound can be applied in preparation of medicaments for preventing and treating aging and preventing or / and treating age-related diseases. Simultaneously, the cucurbitacin mixture and the cucurbitaceae type compound can also be applied in preparation of nutritional compositions for delaying aging and preventing age-related diseases. The compound can also be used as a lead compound for optimizing the structure and can be applied in preparation of medicaments for delaying aging and preventing or / and treating age-related diseases. The general formula of the structure of the compound is shown in the specification.
Description
technical field [0001] The invention belongs to the field of medicine and food of compounds, and relates to the preparation method of the melon pedicle tetracyclic triterpene cucurbitacin mixture, the compound and its derivatives, as well as the application in the preparation of anti-aging diseasemedicine and the preparation of nutritional composition. Background technique [0002] With the improvement of medical conditions, the average life expectancy of human beings is continuously extending, and the problem of population aging is gradually deepening. By the end of 2006, there were 100 million people over the age of 65, accounting for 7.9% of the total population. It is estimated that when the population reaches its peak in 2050, the total elderly population will exceed 400 million, and the aging level will advance to more than 30%, which is close to the sum of the world's elderly population in 1980. [0003] The aging of the population brings about the increasing incide...
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