Periplaneta americana extract microgel and preparation method thereof

A technology of Periplaneta americana and its extract, which is applied in the field of pharmaceutical preparations, can solve the problem of general gel agent film-forming adhesion and uniformity, unsatisfactory cure rate, and difficulty in controlling gelation time, gelation strength and gelation temperature And other issues

Active Publication Date: 2013-11-27
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The weak point when these prior art treatment wounds is that the cure rate is not ideal enough and the patient's adaptability is relatively poor, traces it to its cause: 1. solution is easily lost, and the duration of drug effect is short, needs repeated administration, and it is inconvenient for the patient to use
② Ordinary gels have average adhesion and uniformity in film formation, short drug action time, and require multiple administrations
③In-situ gelation is difficult to control gelation time, gelation strength and gelation temperature

Method used

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  • Periplaneta americana extract microgel and preparation method thereof
  • Periplaneta americana extract microgel and preparation method thereof
  • Periplaneta americana extract microgel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] A kind of Periplaneta americana extract microgel and preparation method thereof, the steps are as follows:

[0023] a. Put 200g of hydroxypropyl cellulose in a beaker, inject 2000ml of deionized water, heat it in a water bath to 60°C, and stir continuously to dissolve it completely.

[0024] b. Add 20g of potassium permanganate to the above solution and keep stirring for 24 hours.

[0025] c. Pour the above solution into a three-necked flask, adjust the pH value to 7.0 with hydrochloric acid solution, continue to feed nitrogen gas for 30 minutes under stirring, raise the temperature to 75°C, and then add 60g of glyceryl acrylate to carry out graft polymerization reaction, which lasts for 6 hours.

[0026] d. Put the above mixture into a centrifuge for separation, redisperse the separated sediment with deionized water, and repeat this centrifugation step three times. Then place it in an oven and dry it at 600°C to constant weight to obtain hydroxypropyl cellulose-glycer...

Embodiment 2

[0030] A kind of Periplaneta americana extract microgel and preparation method thereof, the steps are as follows:

[0031] a. Put 100g of carboxymethyl cellulose in a beaker, inject 1000ml of deionized water, heat it in a water bath to 60°C, and stir continuously to dissolve it completely.

[0032] b. Add 80 g of sodium periodate to the above solution and keep stirring for 20 hours.

[0033] c. Pour the above solution into a three-necked flask, adjust the pH value to 7.0 with hydrochloric acid solution, continue to feed nitrogen gas for 60 minutes while stirring, and raise the temperature to 70. ℃, and then add 100 g of polyacrylic acid to carry out graft polymerization reaction, which lasts for 8 hours.

[0034] d. Put the above mixture into a centrifuge for separation, redisperse the separated sediment with deionized water, and repeat this centrifugation step three times. Then place it in an oven and dry it at 60° C. to a constant weight to obtain a carboxymethylcellulose-...

Embodiment 3

[0037] A kind of Periplaneta americana extract microgel and preparation method thereof, the steps are as follows:

[0038] a. Put 150g of methylcellulose in a beaker, inject 1000ml of deionized water, heat the water bath to 80°C, and stir continuously to dissolve it completely;

[0039] b. Add 50 g of potassium persulfate to the above solution and keep stirring for 12 hours.

[0040] c. Pour the above solution into a three-necked flask, adjust the pH value to 6.8 with hydrochloric acid solution, continue to feed nitrogen gas for 45 minutes under stirring, raise the temperature to 60°C, and then add 50g of hydroxypropyl β-cyclodextrin for graft polymerization. Lasts 5 hours.

[0041] d. Put the above mixture into a centrifuge for separation, redisperse the separated sediment with deionized water, and repeat this centrifugation step three times. Then place it in an oven and dry it at 60° C. to a constant weight to obtain a methyl cellulose-hydroxypropyl β-cyclodextrin copolyme...

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Abstract

The invention provides an external periplaneta americana preparation and a preparation method thereof. The external periplaneta americana preparation can be used for obviously increasing the preservation of periplaneta americana extracts in skins, thus adding granulation tissues and better accelerating wound healing. The external periplaneta americana preparation is used for the surfaces of incised wounds, traumas, ulcers, fistulas, burns, scalds and bedsores as well as inflammations and ulcers of eyes, oral cavities, nasal cavities and vaginal mucosas.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a microgel formulation of Periplaneta americana extract. Background technique [0002] The American cockroach is native to South America and is the largest insect in the family Blatella. The adult body is 29-35 mm long, reddish brown, with wings longer than the end of the abdomen. The antennae are very long, and there is a large butterfly-shaped brown stripe in the middle of the pronotum, and a complete yellow stripe on the rear edge of the stripe. It has a wide range of food habits. The components of Periplaneta americana can promote blood circulation and dissipate blood stasis, detoxify and eliminate malnutrition, diuretic and detumescence. Kangfuxin liquid is a marketed product of the dried worm body extract of Periplaneta americana approved by the State Food and Drug Administration. It can be used clinically to treat wounds of golden sores, trauma, ulc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K9/06A61K47/38A61K47/40A61P17/02A61P1/02A61P27/02A61P15/02A61P11/02
Inventor 陈光健
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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