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Screening method of active pharmaceutical ingredient

A drug activity and screening method technology, applied in the medical field, can solve the problems of limited material separation parameters, simultaneous detection and effective separation of difficult substances, etc.

Inactive Publication Date: 2013-12-11
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

Due to the limited types of material separation parameters in the existing technology, it is difficult to simultaneously detect and effectively separate these substances in biological fluid samples, which has become a bottleneck problem in the research of active ingredients of traditional Chinese medicine.

Method used

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  • Screening method of active pharmaceutical ingredient
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Embodiment Construction

[0029] The invention provides a method for screening active pharmaceutical ingredients, the method comprising the following steps:

[0030] 1) Preliminary determination of the active ingredients of the drug:

[0031] 1.1) Obtain the pathological drug efficacy index of the pathological body:

[0032] 1.1.1) Establish the pathological model of the pathological body;

[0033] 1.1.2) Inject the drug whose active ingredient is to be determined into the pathological body;

[0034] 1.1.3) Detect various pathological drug efficacy indicators of the pathological body that has been injected with the drug whose active ingredient is to be determined according to conventional detection methods.

[0035] 1.2) According to the pathological drug efficacy index of the pathological body obtained in step 1.1), obtain the moment of the maximum drug effect point and the moment of the minimum drug effect point of the drug whose active ingredient is to be determined;

[0036] 1.3) Obtain the whol...

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Abstract

The invention discloses a screening method of active pharmaceutical ingredient. The screening method comprises the following steps: 1) primarily determining the active pharmaceutical ingredient: 1.1) obtaining the pathological pharmacodynamic indexes of a pathological body; 1.2) obtaining the maximal pharmacodynamic point moment and the minimal pharmacodynamic point moment of a medicament with active pharmaceutical ingredient to be determined; 1.3) obtaining the whole blood and / or body fluid of the pathological body; 1.4) creating full-fingerprints; 1.5) comparing the full-fingerprints, wherein the part having the maximal contrast in the full-fingerprints is the primarily determined active pharmaceutical ingredient, and the part having the maximal contrast is the part having the maximal chromatographic peak change in the full-fingerprint of the maximal pharmacodynamic point moment and the full-fingerprint of the minimal pharmacodynamic point moment; 2) obtaining the primarily determined active pharmaceutical ingredient; and 3) detecting, screening and determining the active pharmaceutical ingredient. The screening method of active pharmaceutical ingredient can be used for accurately and quickly determining the active ingredient in a traditional Chinese medicine.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a screening method for active ingredients of medicines, in particular to a screening method for active ingredients of medicines guided by drug efficacy and using microemulsion as a separation medium. Background technique [0002] Traditional Chinese medicine has a long history and remarkable curative effect, but the basic research of traditional Chinese medicine is relatively weak, the chemical composition of most traditional Chinese medicine has not been touched, and the research on active ingredients is even impossible to carry out. Among them, the main reason restricting the development and competition of Chinese medicines in the international market is the lack of effective research methods for the active ingredients of Chinese medicines. The commonly used research method is to extract a single component of traditional Chinese medicine or extract a certain fraction, and then conduct pha...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/34
Inventor 王超文爱东吴寅贾艳艳肖茜杨志福杨静赵超李玉文贾娜李锐莉张维曹珊珊王璐崔佳
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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