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Chlorogenic acid powder-injection and preparation method thereof

A technology of powder injection and chlorogenic acid, which is applied in the field of chlorogenic acid powder injection, can solve the problem of low bioavailability of oral administration, and achieve the effect of reliable action, good stability and high bioavailability

Active Publication Date: 2013-12-18
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Chlorogenic acid is a polyphenolic compound. Experimental studies have proved that it is unstable under acid, alkali, light and high temperature conditions. The literature reports of Zhou Honghao, 01thof MR and Gonthir MP show that chlorogenic acid is an unstable polyphenolic compound. And it is easily affected by factors such as digestive tract flora, and the bioavailability of oral administration is low. It is best to use blood vessel administration, so the injection dosage form is a better dosage form of the drug

Method used

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  • Chlorogenic acid powder-injection and preparation method thereof
  • Chlorogenic acid powder-injection and preparation method thereof
  • Chlorogenic acid powder-injection and preparation method thereof

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Embodiment 1

[0024] Example 1 Selection test of auxiliary materials for chlorogenic acid powder injection of the present invention

[0025] Experimental studies on the solubility of chlorogenic acid bulk drugs show that the sample is easily soluble in methanol and ethanol, acetone, and very slightly soluble in ethyl acetate; the solubility in water is about 2%.

[0026] The results of the experimental study on moisture absorption show that chlorogenic acid has a slight moisture absorption property.

[0027] The results of studies on the stability of raw materials show that chlorogenic acid is sensitive to light and heat.

[0028] Chlorogenic acid is a polyphenol compound, which is easily oxidized. It should be considered whether to add antioxidants in the formulation study; the solubility of chlorogenic acid in water is about 2%, and the concentration of the solution should be within 2% when preparing the solution; green The original acid has hygroscopicity, and the humidity of the preparation res...

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Abstract

The invention provides a chlorogenic acid powder-injection. The chlorogenic acid powder-injection is prepared from the following raw materials in parts by weight: 1-120 parts of chlorogenic acid, 1-320 parts of a bracket agent and 1-8 parts of an antioxidant. The invention further provides a preparation method of the powder-injection. The chlorogenic acid powder-injection disclosed by the invention has good stability, strong re-solubility and safety in clinical use.

Description

Technical field [0001] The invention relates to a chlorogenic acid powder injection. Background technique [0002] Chlorogenic acid is a polyphenol compound. Experimental studies have shown that it is unstable under acid, alkali, light and high temperature conditions. Literature reports such as Zhou Honghao, 01thof MR and Gonthir MP indicate that chlorogenic acid is an unstable polyphenol compound. And it is susceptible to factors such as digestive tract flora. The bioavailability of oral administration is low, and vascular administration is best. Therefore, the injection dosage form is the better dosage form of the drug. Chlorogenic acid is unstable in aqueous solution, so liquid dosage form is not suitable. Summary of the invention [0003] The technical solution of the present invention is to provide a chlorogenic acid powder injection, and another technical solution of the present invention is to provide a preparation method of the chlorogenic acid powder injection. [0004] T...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/216A61K47/02A61K47/10
Inventor 张洁黄英杨华蓉田晨煦严永江朱丽娜黄望
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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