Cold-curing preparation and detection method for intermediate product

A detection method and preparation technology are applied in the detection of sensitized preparations and intermediate products, and in the field of pharmaceuticals, which can solve the problems of effective control of the content of blue cloth and Chlorophytum and control of unfavorable product quality.

Active Publication Date: 2013-12-25
GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lanbuzheng, iron chopsticks, Hibiscus leaf, Perilla, Chlorophytum, Malancao, and Schizonepeta are the characteristic index components of the sensitizing preparations, but in the existing quality standards for sensitizing preparations, there is no specificity for bluecloth and Effective control of the content of Chlorophytum chinensis is not conducive to the quality control of the product by manufacturers and supervisory departments

Method used

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  • Cold-curing preparation and detection method for intermediate product
  • Cold-curing preparation and detection method for intermediate product
  • Cold-curing preparation and detection method for intermediate product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] The intermediate product of the present invention is prepared in the following way: Weigh 65g of blue cloth, 60g of iron chopsticks, 50g of Hibiscus leaves, 50g of Perilla, 50g of Chlorophytum 50g, 75g of Malangrass and 50g of Schizonepeta, add water and decoct 2 times, each time for 1 hour , filter, and combine the filtrates to obtain an intermediate product.

[0129] Described detection method is: measure according to Chinese Pharmacopoeia high-performance liquid chromatography;

[0130] Chromatographic conditions: chromatographic column DiamonsilC18 (250×4.6mm, 5μm); mobile phase methanol-0.1% phosphoric acid solution gradient elution, the elution gradient is shown in the table below; detection wavelength 280nm; flow rate 1mL min -1 ;The column temperature is 30°C;

[0131] HPLC gradient elution conditions of gallic acid and cumulocyanin:

[0132]

[0133] Preparation of the reference substance solution: Accurately weigh 0.01221g of the gallic acid reference sub...

Embodiment 2

[0138] The syrup of the present invention is prepared in this way: 65g of blue cloth, 60g of iron chopsticks, 50g of Hibiscus leaves, 50g of perilla, 50g of Chlorophytum 50g, 75g of Malan grass, 50g of Schizonepeta, 0.2g of menthol, 4g of sodium benzoate, hydroxy 0.4g of phenethyl ester, 0.5g of citric acid, 0.5g of red bayberry essence, 300g of sucrose, decoct the above seven medicinal materials with water twice, each time for 1 hour, filter, combine the filtrate, let stand for 24 hours to precipitate, take Concentrate the supernatant to a clear paste with a relative density of 1.01-1.09, add simple syrup (sucrose and water 1:1), menthol, sodium benzoate, ethylparaben, citric acid, bayberry essence, and stir well to obtain 1000ml syrup.

[0139] Described detection method is: measure according to Chinese Pharmacopoeia high-performance liquid chromatography;

[0140] Chromatographic conditions: chromatographic column DiamonsilC18 (250×4.6mm, 5μm); mobile phase methanol-0.1% p...

Embodiment 3

[0148] The mixture of the present invention is prepared like this: 80g of blue cloth, 70g of iron chopsticks, 60g of hibiscus leaves, 60g of perilla, 60g of Chlorophytum 60g, 85g of Malan grass, 60g of Schizonepeta, 0.3g of menthol, 4g of sodium benzoate, and ethyl hydroxyphenyl Ester 0.6g, citric acid 06g, decoct the above seven herbs with water for 3 times, 0.5 hours each time, filter, combine the filtrates, let stand for 40 hours to precipitate, take the supernatant and concentrate to a relative density of 1.01-1.09 Add menthol, sodium benzoate, ethylparaben and citric acid, stir well, add water to make the whole amount into 1000ml, fill, sterilize, and get ready.

[0149] Described detection method is: measure according to Chinese Pharmacopoeia high-performance liquid chromatography;

[0150] Chromatographic conditions: chromatographic column DiamonsilC18 (250×4.6mm, 5μm); mobile phase: methanol-0.1% phosphoric acid solution gradient elution, the elution gradient is shown ...

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Abstract

The invention provides a cold-curing preparation and a detection method for an intermediate product. The cold-curing preparation is prepared from Geum japonicum Thunb, Helleborus thibetanus, Folium Hibisci Mutabilis, purple perilla, fewflower lysionotus herb, herba kalimeridis, Schizonepeta, and auxiliary materials. Compared with the prior art, on the basis of current cold-curing preparation quality control, a method for measuring the content of gallic acid and lysionotin of an intermediate product and a preparation is added to the detection method. The detection method is accurate; the sensitivity is high; the repeatability is good; the detection result is stable; and the quality of the cold-curing preparation can be effectively controlled.

Description

technical field [0001] The invention relates to a detection method for a clear preparation and an intermediate product, and belongs to the field of pharmaceutical technology. Background technique [0002] Ganqing preparation is prepared from blue cloth, iron chopsticks, hibiscus leaves, perilla, spider plant, malan grass, nepeta and auxiliary materials. It has the effects of pungent and warm, clearing the lungs and relieving cough, and is used for headaches caused by wind-cold and cold. , chills, fever, runny nose, cough embolism. Lanbuzheng, iron chopsticks, Hibiscus leaf, Perilla, Chlorophytum, Malancao, and Schizonepeta are the characteristic index components of the sensitizing preparations, but in the existing quality standards for sensitizing preparations, there is no specificity for bluecloth and Effective control of the content of Chlorophytum is not conducive to the quality control of the product by manufacturers and supervisory departments. In order to further ens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 田源红李星蔡守宪王晓冬张英马敬源安斯扬熊灿霞夏文
Owner GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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