Process for extracting and purifying total organic acid of aralia cordata

A technology of soil angelica and organic acid, which is applied in the field of medicine, can solve the problems of unpublished separation and purification method of total organic acid extract, and achieve the effects of improving the utilization rate of medicinal materials, saving production costs, and stabilizing the process

Inactive Publication Date: 2014-01-08
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent application 201310016091.3 discloses a process for extracting total organic acids from edible soil Angelica sinensis, which discloses a best technical solution for extracting total organic acids, but the patent application does not disclose the separation and purification method of total organic acids extract

Method used

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  • Process for extracting and purifying total organic acid of aralia cordata
  • Process for extracting and purifying total organic acid of aralia cordata
  • Process for extracting and purifying total organic acid of aralia cordata

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] Embodiment 1: edible soil angelica total organic acid extraction process, it comprises the following steps:

[0123] S1: Weigh edible soil angelica coarse powder, add 95% ethanol whose weight is 8 times that of edible soil angelica coarse powder, heat and reflux extraction twice, each time for 1 hour, filter with suction, combine filtrates, recover ethanol under reduced pressure, and obtain edible soil angelica ethanol extract;

[0124] S2: Weigh the ethanol extract of Angelica sinensis edible soil, and dissolve it in water whose weight is 15 times that of the ethanol extract of Angelica sinensis edible soil, to obtain a sample solution of ethanol extract of Angelica sinensis edible soil;

[0125] S3: Add NaCl to the sample solution of the ethanol extract of Angelica sinensis edible soil to make the mass fraction reach 0.30%, then add a low-priced organic solvent whose weight is twice that of the sample solution of the ethanol extract of Angelica sinensis edible soil, e...

Embodiment 2

[0128] Embodiment 2: edible soil angelica total organic acid extraction process, it comprises the following steps:

[0129] S1: Weigh edible soil angelica coarse powder, add 95% ethanol whose weight is 8 times that of edible soil angelica coarse powder, heat and reflux extraction twice, each time for 1 hour, filter with suction, combine filtrates, recover ethanol under reduced pressure, and obtain edible soil angelica ethanol extract;

[0130] S2: Weigh the ethanol extract of Angelica sinensis edible soil, and dissolve it in water with an amount 20 times the weight of the ethanol extract of Angelica sinensis edible soil, to obtain a sample solution of ethanol extract of Angelica sinensis edible soil;

[0131] S3: Add NaCl to the sample solution of the ethanol extract of Angelica sinensis edible soil to make the mass fraction reach 0.40%, then add a low-priced organic solvent whose weight is 3 times the sample solution of the ethanol extract of Angelica sinensis edible soil, ex...

Embodiment 3

[0134] Embodiment 3: edible soil Angelica total organic acid extraction process, it comprises the following steps:

[0135] S1: Weigh edible soil angelica coarse powder, add 95% ethanol whose weight is 8 times that of edible soil angelica coarse powder, heat and reflux extraction twice, each time for 1 hour, filter with suction, combine filtrates, recover ethanol under reduced pressure, and obtain edible soil angelica ethanol extract;

[0136] S2: Weigh the ethanol extract of Angelica sinensis edible soil, and dissolve it in water whose weight is 25 times that of the ethanol extract of Angelica sinensis edible soil, to obtain a sample solution of ethanol extract of Angelica sinensis edible soil;

[0137] S3: Add NaCl to the sample solution of the ethanol extract of Angelica sinensis edible soil to make the mass fraction reach 0.50%, then add a low-priced organic solvent whose weight is 4 times the sample solution of the ethanol extract of Angelica sinensis edible soil, extract...

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Abstract

The invention discloses a process for extracting and purifying the total organic acid of aralia cordata, which belongs to the technical field of pharmacy, and solves the technical problems of low extraction rate and low purity of the total organic acid of the aralia cordata. The process sequentially comprises the following steps: performing reflux extraction through ethyl alcohol; adding NaCl for salting-out; adding a low-valence/polarity organic solvent for extraction; adding KOH for alkaline treatment; adding concentrated hydrochloric acid for acid deposition; adding NaCl for salting-out; adding the low-valence organic solvent for extraction; performing concentration and drying under reduced pressure to obtain an extract of the total organic acid of the aralia cordata. An optimum aralia cordata organic acid extraction and purification scheme is adopted, so that the total organic acid in the edible aralia cordata can be extracted to the greatest extent, the usage rate of medicinal materials is increased, and the cost is saved; an extraction requirement does not need to be specifically required, and the extraction and purification process is stable, and easy to operate and the total organic acid is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a purification process of edible soil Angelica total organic acid extract. Background technique [0002] Edible soil Angelica is a perennial herb, belonging to the Araliaceae genus Araliaceae. It grows in hillside grass or shade at an altitude of 1300-2500m, and is distributed in Hubei, Anhui, Jiangsu, Guangxi, Jiangxi, Fujian and Taiwan. This product is a kind of traditional Chinese medicine with both medicine and food, and it is also the mainstream variety of commodity Jiuyanduhuo. It has the effects of dispelling wind and harmonizing blood, antipyretic and analgesic, dispelling wind and tonifying deficiency, diuresis and detumescence, and is mainly used to treat rheumatic arthralgia Pain, soreness of the waist and knees, headache and dizziness. Modern medicinal chemistry studies have shown that edible soil angelica is rich in diterpene carboxylic acid, nicotinic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25
Inventor 彭腾杨菁凌智群
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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