Preparation method of fresh ginger total phenols bulk drug of medicine for preventing motion sicknesses

A technology for total phenolics of ginger and motion sickness, which is applied in the field of preparation of new traditional Chinese medicines, can solve the problems of strong side effects, high toxicity of anti-kinesiology drugs, poor effect and the like, and achieves the effects of reduced decomposition and easy control of selectivity

Inactive Publication Date: 2014-01-15
SANJIN GROUP HUNAN SANJIN PHARMA
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AI Technical Summary

Problems solved by technology

[0005] In order to overcome the defects of high toxicity, strong side effects and poor effect of anti-motion sickness drugs on the market today, the object of the present invention is to

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: choose 65kg of two-year-old fresh old ginger without insect erosion and rot and mildew, wash it with water, dry the surface moisture, cut into 2-3mm thin slices, put in an electric blast constant temperature drying box, and dry it at 40 ℃ ventilated and dried to water content below 10%, pulverized through 40 mesh sieves, got ginger powder 7kg. Load ginger powder into supercritical CO 2 In the extraction kettle of the extraction device, at a temperature of 40°C, a pressure of 20Mpa, CO 2 Extraction is carried out under the condition of flow rate of 10kg / h, extraction time is 180min, and then 300g of oleoresin is collected in separator I with a pressure of 10Mpa, which is gingerols extract——total gingerols. An additional 150 g of oil was collected from separator II at a pressure of 6.5 MPa.

Embodiment 2

[0013] Embodiment 2: choose 65kg of two-year-old fresh old ginger without insect erosion and rot and mildew, wash with water, dry the surface moisture, cut into 2-3mm thin slices, put in an electric blast constant temperature drying box, and dry at 45 ℃ ventilated and dried to water content below 10%, pulverized through 40 mesh sieves, got ginger powder 7kg. Load ginger powder into CO 2 In the extraction kettle of the supercritical extraction device, at a temperature of 65°C, a pressure of 50Mpa, CO 2 Extraction is carried out under the condition of flow rate of 10kg / h, the extraction time is 60min, and then 300g of oleoresin is collected in separator I with a pressure of 10Mpa, which is the gingerols extract——total gingerols. An additional 150 g of oil was collected from separator II at a pressure of 6.5 MPa.

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Abstract

A preparation method of a fresh ginger total phenols bulk drug of a medicine for preventing motion sicknesses comprises the following steps of: (1) drying and smashing; and (2) supercritical extraction: adding prepared fresh ginger powder into an extraction kettle of a carbon dioxide CO2 supercritical extraction device, extracting for 60-180 min under the conditions that the temperature is 40-65 DEG C, the pressure is 20-50 MPa and the CO2 flow speed is 10kg/h, and then collecting oleoresin material by using a separator I with the pressure of 10 MPa so as to obtain the fresh ginger phenols extract, namely fresh ginger total phenols. The preparation method has the advantages that the extract has no residual solvent, the selectivity is easy to control, and the extraction efficiency is high. As the CO2 is inactive, and the extraction and separation also can be completed in a relatively short time at a normal temperature or relatively low temperature, the decomposition of unsteady components is reduced. The fresh ginger total phenols medicine extracted by the method can strengthen mid-energy and harmonize stomach, eliminate phlegm and prevent emesis and is a good medicine for preventing motion sicknesses such as carsickness and seasickness.

Description

technical field [0001] The invention relates to a preparation method of a new traditional Chinese medicine, in particular to a preparation method of ginger total phenols used for preventing motion sickness such as motion sickness and seasickness. Background technique [0002] According to relevant research, the incidence rate of motion sickness is 4%, that of long-distance seasickness is 25%-30%, and that of airsickness is 10%. About 1 / 3 of the population is susceptible to motion sickness, and the symptoms of motion sickness usually develop progressively. From stomach discomfort, nausea, increased salivation, pale complexion, cold sweats, dizziness, headache, and then developed to retching, vomiting, lethargy, and apathy. Those with severe vomiting may even become dehydrated and exhausted. It occurs when people ride in cars, boats, planes, rides, or sailing, aviation, aerospace simulations or actual operations. According to the research understanding of the pathogenesis of...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/08
Inventor 邹节明杨银芝陈林
Owner SANJIN GROUP HUNAN SANJIN PHARMA
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