Substituted N-((1', 3'-azole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound and applications thereof

A technology for compounds and solvates, applied in the field of preparing anti-tuberculosis drugs, can solve the problems of no new anti-tuberculosis drugs and the like
CN103570705AActive Publication Date: 2014-02-12MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2014-02-12

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Abstract

The invention discloses a substituted N-((1', 3'-azole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound represented by formula I, a preparation method thereof, and applications of the substituted N-((1', 3'-oxazole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound in preparation of antituberculous drugs. The substituted N-((1', 3'-azole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound possesses activity on mycobacterium tuberculosis-susceptible strains, and also possesses activity on strains with tolerance on traditional first-line antituberculous drugs such as isoniazide and rifampicin, and is a novel mycobacterium tuberculosis resistant compound with a promising application prospect.
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Description

technical field

[0001] The present invention relates to a class of substituted N-((1',3'-heterazol-4'-yl)-methyl)-4-benzoyl hexahydropyridine compounds, and also relates to the preparation of said compounds The method and its use for the preparation of anti-tuberculosis drugs. Background technique

[0002] Tuberculosis is a chronic infectious disease common to humans, livestock and poultry. In history, it was widely popular all over the world and claimed the lives of hundreds of millions of people. It was called the "white plague" by people. In 1882, Koch discovered that tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mycobacterium tuberculosis, referred to as Mycobacterium tuberculosis). Since the 1950s, due to the continuous discovery and clinical application of various effective chemotherapy drugs, the prevalence of tuberculosis was once under control. However, in recent years, tuberculosis, which was once effectively controlled, has made a ...

Claims

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