New function and application of amarogentin for treating pulmonary arterial hypertension
Patent Information
- Authority / Receiving Office
- CN Β· China
- Current Assignee / Owner
- FOURTH MILITARY MEDICAL UNIVERSITY
- Publication Date
- 2014-03-12
- Estimated Expiration
- Not applicable Β· inactive patent
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Abstract
Description
technical field
[0001] The invention relates to the new action of gentioside in the treatment of pulmonary arterial hypertension and its application in the preparation of medicines for the prevention and treatment of pulmonary arterial hypertension, belonging to the technical field of pharmacological action of compounds. Background technique
[0002] Pulmonary Arterial Hypertension (PAH) is a kind of extremely malignant progressive disease characterized by progressive increase of pulmonary vascular resistance, eventually leading to right heart failure and even death. In the latest evidence-based clinical practice guidelines for the diagnosis and treatment of pulmonary arterial hypertension issued by the American College of Chest Physicians (ACCP), it is defined as mean pulmonary arterial pressure β₯ 25 mmHg, capillary pressure or left atrial pressure β€ 15 mmHg. PAH is divided into two types: primary (PPH) and secondary (SPH). Clinically, the main manifestations are exertional...