A fluorescent molecular imaging system and imaging method based on LED light source

Abstract

The invention discloses a fluorescent molecular imaging system based on an LED light source and an imaging method thereof. The fluorescent molecular imaging system based on the LED light source comprises a light source device, an animal bed, an imaging device and a computer image processing system, wherein the light source device comprises the light source, a light source frame, a switch set, an exciting light filter set and lenses. LEDs are adopted in the light source, the light source comprises multiple sets of LED arrays of different light-emitting wave lengths, and each set of the LED array is connected to the switch set. According to the fluorescent molecular imaging system based on the LED light source and the imaging method thereof, the multiple sets of the LED arrays of different light-emitting lengths are adopted in the light source, the manufacturing technology is simple, price is low, and the LED arrays of different wave lengths can be switched easily according to needs to achieve the excitation of different fluorescent substances. It is firstly proposed that the LEDs serve as the exciting light source of the transmission-type fluorescent molecular imaging system and the exciting light source of a fluorescent molecular tomography system, the imaging system is simple in structure, optical fibers are not needed for transmitting exciting light, and therefore fluorescent molecular tomography can be carried out more efficiently.

Description

technical field [0001] The invention relates to the field of biomedical imaging, in particular to a fluorescent molecular imaging system based on an LED light source and an imaging method thereof. Background technique [0002] Fluorescence molecular imaging system generally mainly includes light source, optical fiber, lens, filter, stage, CCD camera, camera obscura, PC image processing software, motor, etc. From the working mode, the fluorescent molecular imaging system can be divided into two working modes: planar imaging and tomographic imaging. According to the geometric position of the light source and detector, planar imaging can be divided into epi-illumination imaging and transillumination imaging, while tomographic imaging is mainly fluorescence molecular tomography (Fluorescence Molecular Tomography, FMT). FMT is a technology that uses the excitation light and the emitted fluorescence information of the measured sample to reconstruct the three-dimensional distribut...

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Problems solved by technology

However, the above system can only perform reflection fluorescence imaging, but not transmission fluorescence imaging and fluorescence molecular tomography

So far, no research team or company has proposed a fluorescent molecular tomography system that uses LEDs as an excitation light source.

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