Anti-inflammatory application of small molecule compound AG-4

A small molecule compound, AG-4 technology, applied in the field of biotechnology and medicine, can solve the problem of anti-inflammatory compounds without CD147, and achieve the inhibition of inflammatory cell chemotaxis, inhibition of monocytes/macrophages and neutrophils Chemotaxis and inhibition of gelatinase secretion

Active Publication Date: 2014-03-26
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, there are still no reports of anti-inflammatory compounds targeting CD147 at home and abroad

Method used

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  • Anti-inflammatory application of small molecule compound AG-4
  • Anti-inflammatory application of small molecule compound AG-4
  • Anti-inflammatory application of small molecule compound AG-4

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Embodiment Construction

[0026] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific experimental results.

[0027]Previous studies have found that CD147 highly expressed on the surface of monocytes / macrophages and neutrophils in patients with rheumatoid arthritis can promote FLS cells to secrete MMPs, thereby promoting cartilage and bone erosion. CD147 can also promote inflammatory cells to The accumulation of joint lesions aggravates inflammation, thus suggesting that CD147 is involved in the pathogenesis of rheumatoid arthritis. Moreover, in previous studies, the liver cancer monoclonal antibody HAb18 has been successfully used to screen the cDNA library of human liver cancer tissue, and a cDNA fragment encoding HAb18G has been cloned. Query GenBank and found that the open reading frame of the HAb18G gene is highly homologous to the human CD147 molecule. It is a new member of the CD147 family, and the three-dimensional crystal st...

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Abstract

The invention discloses anti-inflammatory application of a small molecule compound AG-4, and application in preparing anti-inflammatory drug. The small molecule compound AG-4 is screened through a candidate drug screening platform combining structural biology, information biology and biological activity determination. The small molecule compound AG-4 can realize specific binding with CD147 protein to inhibit inflammatory cell chemotaxis and secretion of chemotaxis; the invention is also suitable for preparing medicines for treating CD147 protein high expression related diseases (such as rheumatoid arthritis).

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine, and in particular relates to the anti-inflammatory application of small molecular compound AG-4. Background technique [0002] Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease with a global incidence of 1%. There are more than 5 million RA patients in my country. The disability rate of RA patients is high. Within the first 2 years of onset, about 75% of patients have joint damage, and 80% of patients suffer from joint deformation and disability after 20 years. Some patients' disease progresses rapidly and even leads to death. Therefore, the treatment of RA has always been the focus of medical attention. At present, the pathogenesis of RA is not clear, thus limiting the progress of treatment. [0003] CD147 molecule is a widely expressed glycoprotein and a member of the immunoglobulin superfamily. CD147 is widely expressed in various types of cells, espe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4035A61P29/00A61P19/02
Inventor 汪莉朱平王聪华付之光李郁蒋建利陈志南
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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