39results about How to "Inhibition of chemotaxis" patented technology

The invention relates to an ophthalmic controlled release system of long-action low molecular heparin which comprises the low molecular heparin as drug and a drug carrier made from synthesized or natural biodegradable high molecular materials and is characterized in that the proportion range of the low molecular heparin and the drug carrier is (1:8) to (5:1); the average molecular mass of the lowmolecular heparin is less than 8000 Dalton; the molecules less than 8000 Dalton, the salt compounds of the low molecular heparin such as sodium salt, calcium salt and kali salt included, take up not less than 60 percent of the total molecules of the low molecular heparin; the synthesized or natural biodegradable high molecular materials are polyglycolic acid and gelatin or bletilia striata gelatinrespectively. The ophthalmic controlled release system of long-action low molecular heparin can effectively inhibit the proliferation and migration of lenticular epithelia and fibroblasts in eyes, reduce fibrinous exudates post operation, alleviate inflammatory reaction post operation and prevent posterior capsular opacification, thereby inhibiting the occurrence of after-cataract; meanwhile, theophthalmic controlled release system of long-action low molecular heparin inhibits the proliferation of retinal pigment epithelium and fibroblasts, thus inhibiting the proliferative vitreoretinopathy(PVR).

The invention provides an oral Andrias davidianus liquid for eyesight improvement. The oral liquid is prepared through using the following raw materials, by weight, 6-10 parts of an Andrias davidianus eye, 8-12 parts of an Andrias davidianus liver, 40-60 parts of Andrias davidianus skin, 8-12 parts of Lycium Chinense, 8-12 parts of wild chrysanthemum flower, 8-12 parts of white peony root, 18-22 parts of unprepared rehmannia root, 8-12 parts of honey, and 8-12 parts of morchella. A preparation method of the oral liquid comprises the following steps: adding water having a weight 2-3 times the raw materials except honey to the raw materials except honey, decocting with a slow fire for 1.5-2h, filtering, adding honey, uniformly mixing, cooling, and canning to obtain the oral Andrias davidianus liquid for eyesight improvement. The oral Andrias davidianus liquid has the efficacies of liver cleaning, eyesight improving, kidney yin nourishing and the like, and can improve the organism immunity, promote the brain development, prevent senile dementia, protect the eyesight and delay ageing through frequent drinking.

The invention provides an oral giant salamander liquid for brain strengthening. The oral liquid is prepared through using the following raw materials, by weight, 150-250 parts of a giant salamander brain, 10-20 parts of a giant salamander liver, 4-8 parts of ginseng, 15-25 parts of Lycium Chinense, 25-35 parts of lotus seed, 8-12 parts of brown sugar, 8-12 parts of walnut kernel, 15-25 parts of Dioscorea opposita and 15-25 parts of red date. A preparation method of the oral liquid comprises the following steps: adding water having a weight 2-3 times raw materials except brown sugar to the raw materials except brown sugar, decocting with a slow fire for 1.5-2h, filtering, adding brown sugar, uniformly mixing, filtering, cooling, and canning. The oral liquid has the efficacies of essence replenishing, blood tonifying, brain strengthening, intelligence developing, liver and kidney nourishing, heart fire clearing, vexation eliminating, qi tonifying, blood nourishing and the like, and can be adapted to all age groups.

The invention discloses 1-(5-(3-((4-chlorobenzyl)amino)-2-hydroxypropoxy)-2-methyl-1-(p-tolyl)-1hydro-indole- 3-yl) ethyl ketone for the treatment or prevention of inflammatory diseases, for the prevention and / or alleviation and / or auxiliary treatment and / or treatment of inflammatory diseases, such as bronchitis, pneumonia, hepatitis, rhinitis, enteritis, gastritis , nephritis, dermatitis, prostatitis, vaginitis, rheumatism, etc. The present invention 1-(5-(3-((4-chlorobenzyl) amino)-2-hydroxypropoxy)-2-methyl-1-(p-tolyl)-1 hydrogen-indole-3- Base) ethyl ketone has specific inhibitory effect on PI3Kγ, and has inhibitory effect on inflammatory cell proliferation and chemotaxis. The compound of the present invention can inhibit inflammatory response by inhibiting PI3Kγ.