A preparation method of a pharmaceutical composition for treating coronary heart disease angina pectoris
A coronary heart disease angina pectoris and composition technology, which is applied in the field of traditional Chinese medicine composition, can solve problems such as great differences in treatment responses, unsatisfactory anti-platelet drug efficacy, confusion in the selection and application of antithrombin drugs, etc.
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Embodiment 1
[0079] Take 10 parts of raw Puhuang, 10 parts of Salvia miltiorrhiza, 11 parts of Alisma, 10 parts of Panax notoginseng, add 90% ethanol to reflux twice for 2 hours each time, combine alcohol extracts, and concentrate to relative density at 80°C 1.1 to 1.3 clear ointment, set aside; take 11 parts of dried tangerine peel, 11 parts of Chuanxiong Rhizoma Rhizoma Chuanxiong, add 20 times the amount of water to extract the volatile oil for 8 hours, collect the volatile oil, and use β-cyclodextrin for later use; 11 parts of French pinellia, 10 parts of Radix Polygoni Multiflori, 10 parts of kelp, 11 parts of medlar, 10 parts of cassia seed, 10 parts of raw hawthorn. The relative density at ℃ is 1.20~1.25, and it is mixed with alcohol concentrate to obtain a clear paste. Separately take the dextrin, sweetener and the above-mentioned spare clear paste to make granules by one-step spray-drying granulation method, granulate, add the spare β-cyclodextrin inclusion complex, mix well, and ...
Embodiment 2
[0081] Take 20 parts of raw Puhuang, 20 parts of Salvia miltiorrhiza, 22 parts of Alisma, 20 parts of Panax notoginseng, add appropriate amount of 90% ethanol to reflux twice for 2 hours each time, combine alcohol extracts, concentrate to relative density at 80°C 1.1-1.3 clear ointment, set aside; take 22 parts of tangerine peel and 22 parts of Chuanxiong two herbs, add 20 times the amount of water to extract the volatile oil for 8 hours, collect the volatile oil, and use β-cyclodextrin for later use; mix the above-mentioned medicinal residues with 22 parts of French pinellia, 20 parts of Polygonum multiflorum, 20 parts of kelp, 22 parts of medlar, 20 parts of cassia seed, 20 parts of raw hawthorn. The relative density at ℃ is 1.20~1.25, and it is mixed with alcohol concentrate to obtain a clear paste. Separately take dextrin, sweetener and the above-mentioned standby clear paste to make granules by spray-drying one-step granulation method, granulate, add the standby β-cyclode...
Embodiment 3
[0083] Take 40 parts of raw Puhuang, 40 parts of Salvia miltiorrhiza, 45 parts of Alisma, 40 parts of Panax notoginseng, add appropriate amount of 90% ethanol to reflux twice for 2 hours each time, combine alcohol extracts, concentrate to relative density at 80 °C 1.1 to 1.3 clear ointment, set aside; take 45 parts of tangerine peel, 45 parts of Chuanxiong two medicinal materials, add 20 times the amount of water to extract the volatile oil for 8 hours, collect the volatile oil, and use β-cyclodextrin for later use; mix the above-mentioned medicinal residues with 45 parts of French pinellia, 40 parts of Radix Polygoni Multiflori, 40 parts of kelp, 45 parts of medlar, 40 parts of cassia seed, 40 parts of raw hawthorn. The relative density at ℃ is 1.20~1.25, and it is mixed with alcohol concentrate to obtain a clear paste. Separately take dextrin, sweetener and the above-mentioned standby clear paste to make granules by spray-drying one-step granulation method, granulate, add th...
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