Brushite-calcium silicate/chitosan composite bone cement with rapid and controllable biodegrability

A bioactive, calcium-permeable phosphite technology, used in medical science, prosthesis, etc., can solve the problems of scattering, limiting the application and research of bone cement, tissue toxicity and side effects, and achieve the effect of preventing scattering and continuous and rapid degradation.

Active Publication Date: 2014-03-26
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hydroxyapatite bone cement occupies a low position in the current clinical application, in-depth research in recent years has found that: due to the slow degradation rate of this type of bone cement, its bone reconstruction ability is greatly limited
Brushite bone cement was first developed in 1989 by Mirtchi and By MCPM(Ca(H 2 PO 4 )·H 2 O) and β-TCP (Ca 3 (PO 4 ) 2 ) mixed powder with water, the brushite bone cement prepared by this original formula solidifies too fast, solidifies within 30s, and the mechanical strength is not high, only 1MPa; and the solidified body of this kind ...

Method used

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  • Brushite-calcium silicate/chitosan composite bone cement with rapid and controllable biodegrability
  • Brushite-calcium silicate/chitosan composite bone cement with rapid and controllable biodegrability
  • Brushite-calcium silicate/chitosan composite bone cement with rapid and controllable biodegrability

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Rapidly degradable bioactive brushite-calcium silicate / chitosan composite bone cement, which is composed of composite powder 1, composite powder 2 and solidification liquid, each component is stored separately, wherein: the composite Powder one consists of MCPM1.2g, MgHPO 4 ·3H 2 O 0.2g is obtained by mixing, and the composite powder is composed of β-TCP(Ca 3 (PO 4 ) 2 )0.7g, α-TCP (Ca 3 (PO 4 ) 2 )0.7g, calcium silicate ((CaO) 7 (SiO 2 ) 3 ) 1.2g, the solidified liquid is an aqueous solution of chitosan and citric acid, the mass concentration of citric acid in the solidified liquid is 0.06g / ml, the mass concentration of chitosan is 0.05g / ml, the composite powder and the ratio of the total mass of the composite powder 2 to the volume of the solidified liquid is 1.5g / mL.

[0020] Preparation of solidified solution: Dissolve 2.4g of citric acid in 40ml of deionized water, then slowly add 2g of chitosan into the citric acid solution stirred at a constant speed, a...

Embodiment 2

[0024] Rapidly degradable bioactive brushite-calcium silicate / chitosan composite bone cement, which is composed of composite powder 1, composite powder 2 and solidification liquid, each component is stored separately, wherein: the composite Powder one consists of MCPM1.2g, MgHPO 4 ·3H 2 O 0.2g is obtained by mixing, and the composite powder is composed of β-TCP(Ca 3(PO 4 ) 2 )0.2g, α-TCP (Ca 3 (PO 4 ) 2 )1.2g, calcium silicate ((CaO) 7 (SiO 2 ) 3 ) 1.2g, the solidified liquid is a solution of chitosan and citric acid, the mass concentration of citric acid in the solidified liquid is 0.175g / ml, the mass concentration of chitosan is 0.14g / ml, the composite powder and the ratio of the total mass of the composite powder 2 to the volume of the solidified liquid is 2.0 g / ml.

[0025] The configuration of the solidified solution: Dissolve 7g of citric acid in 40ml of deionized water, then slowly add 5.6g of chitosan into the citric acid solution stirred at a constant speed,...

Embodiment 3

[0029] Rapidly degradable bioactive brushite-calcium silicate / chitosan composite bone cement, which is composed of composite powder 1, composite powder 2 and solidification liquid, each component is stored separately, wherein: the composite Powder one consists of MCPM2.09g, MgHPO 4 ·3H 2 O 0.2g is obtained by mixing, and the composite powder is composed of β-TCP(Ca 3 (PO 4 ) 2 ) 0.51g, dicalcium silicate 1.2g are mixed, and solidification liquid is the solution of chitosan and citric acid, and the mass concentration of citric acid in the solidification liquid is 0.175g / ml, and the mass concentration of chitosan is 0.14g / ml, the ratio of the total mass of composite powder 1 and composite powder 2 to the volume of solidified liquid is 2.0 g / mL.

[0030] The preparation of solidified liquid is the same as embodiment 2.

[0031] Method of use: After mechanically mixing the above-mentioned composite powder 1 and composite powder 2, add a corresponding amount of solidification...

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Abstract

The invention relates to brushite-calcium silicate/chitosan composite bone cement with rapid and controllable biodegrability. The brushite-calcium silicate/chitosan composite bone cement comprises three parts of composite power I, composite powder II and a curing liquid which are stored separately, wherein the composite power I is formed by mixing MCPM (monocalcium phosphate monohydrate) and MgHPO4*3H2O; the composite powder II is formed by mixing calcium phosphate and calcium silicate with a molar ratio of calcium and silicon larger than 1:1, and calcium phosphate is a mixture of one or two of beta-TPC (tertiary calcium phosphate) and alpha-TCP; the curing liquid adopts a chitosan and citric acid solution; and the mass ratio of the composite power I to the composite power II is (0.3-1.5):1, and the ratio of the total mass of the composite power I and the composite power II to the volume of the curing liquid, namely the solid-to-liquid ratio is (1.5-2.7):1 g/ml. On the basis of that appropriate curing time and certain compressive strength are guaranteed, the brushite-calcium silicate/chitosan composite bone cement has continuous, rapid and controllable biodegrability.

Description

technical field [0001] The invention relates to a fast and controllable degradable calcium phosphate composite bone cement, which belongs to the field of medical hard tissue repair materials. Background technique [0002] Calcium phosphate bone cements are mainly divided into two categories: hydroxyapatite bone cement and brushite bone cement. Although hydroxyapatite bone cement occupies a low position in the current clinical application, in-depth research in recent years has found that: due to the slow degradation rate of this type of bone cement, its bone reconstruction ability is greatly limited. Brushite bone cement was first developed in 1989 by Mirtchi and By MCPM(Ca(H 2 PO 4 )·H 2 O) and β-TCP (Ca 3 (PO 4 ) 2 ) mixed powder with water, the brushite bone cement prepared by this original formula solidifies too fast, solidifies within 30s, and the mechanical strength is not high, only 1MPa; and the solidified body of this kind of bone cement degrades in vivo Dur...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/12A61L27/02A61L27/00A61L27/50
Inventor 张胜民李尚霖马军
Owner HUAZHONG UNIV OF SCI & TECH
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