Brushite-calcium silicate/chitosan composite bone cement with rapid and controllable biodegrability

Abstract

The invention relates to brushite-calcium silicate / chitosan composite bone cement with rapid and controllable biodegrability. The brushite-calcium silicate / chitosan composite bone cement comprises three parts of composite power I, composite powder II and a curing liquid which are stored separately, wherein the composite power I is formed by mixing MCPM (monocalcium phosphate monohydrate) and MgHPO4*3H2O; the composite powder II is formed by mixing calcium phosphate and calcium silicate with a molar ratio of calcium and silicon larger than 1:1, and calcium phosphate is a mixture of one or two of beta-TPC (tertiary calcium phosphate) and alpha-TCP; the curing liquid adopts a chitosan and citric acid solution; and the mass ratio of the composite power I to the composite power II is (0.3-1.5):1, and the ratio of the total mass of the composite power I and the composite power II to the volume of the curing liquid, namely the solid-to-liquid ratio is (1.5-2.7):1 g / ml. On the basis of that appropriate curing time and certain compressive strength are guaranteed, the brushite-calcium silicate / chitosan composite bone cement has continuous, rapid and controllable biodegrability.

Description

technical field [0001] The invention relates to a fast and controllable degradable calcium phosphate composite bone cement, which belongs to the field of medical hard tissue repair materials. Background technique [0002] Calcium phosphate bone cements are mainly divided into two categories: hydroxyapatite bone cement and brushite bone cement. Although hydroxyapatite bone cement occupies a low position in the current clinical application, in-depth research in recent years has found that: due to the slow degradation rate of this type of bone cement, its bone reconstruction ability is greatly limited. Brushite bone cement was first developed in 1989 by Mirtchi and By MCPM(Ca(H 2 PO 4 )·H 2 O) and β-TCP (Ca 3 (PO 4 ) 2 ) mixed powder with water, the brushite bone cement prepared by this original formula solidifies too fast, solidifies within 30s, and the mechanical strength is not high, only 1MPa; and the solidified body of this kind of bone cement degrades in vivo Dur...

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Problems solved by technology

Although hydroxyapatite bone cement occupies a low position in the current clinical application, in-depth research in recent years has found that: due to the slow degradation rate of this type of bone cement, its bone reconstruction ability is greatly limited

Brushite bone cement was first developed in 1989 by Mirtchi and By MCPM(Ca(H 2 PO 4 )·H 2 O) and β-TCP (Ca 3 (PO 4 ) 2 ) mixed powder with water, the brushite bone cement prepared by this original formula solidifies too fast, solidifies within 30s, and the mechanical strength is not high, only 1MPa; and the solidified body of this kind of bone cement degrades in vivo During the process, hydrogen ions will be released, resulting in a local pH that is too low, causing certain toxic and side effects on the tissue, and a large amount of particulate matter will be scattered, and the scattered particles will cause damage to other organs of the human body after entering the human circulatory system; Therefore, there is a tendency to transform into hydroxyapatite inside the material, which leads to defects such as degradation of the material's degradation ability, which greatly limits the application and research of this type of bone cement.

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