A source core carrier of radioactive particles and its preparation process

A technology of radioactive particles and source core carriers, which is applied in the preparation of radioactive carriers and X-ray contrast agents, etc., can solve the problems of low I energy, low utilization rate, and reduced utilization rate, so as to improve utilization rate, reduce absorbed dose, reduce The effect of operating volume

Active Publication Date: 2015-09-23
HTA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low energy of 103Pd and 125I, silver rods are used as carriers for 103Pd or 125I The absorption rate of 103Pd or 125I is reduced due to the high absorption rate
For example, 0.5 mm×3.0 mm silver rod absorbs about 34% of 125I, and 103Pd is as high as 60%, and the utilization rate of 103Pd and 125I is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A source core carrier of radioactive particles, the carrier is a carbon rod whose surface is evenly covered with a silver layer.

[0024] A preparation process for a source core carrier of radioactive particles, the process comprises the following steps:

[0025] Place a carbon rod with a diameter of φ0.3mm in a mixed solution consisting of 1mmol / L silver nitrate, 25mmol / L ethylenediaminetetraacetic acid disodium, 2mol / L ammonium hydroxide and 6mmol / L hydrazine hydrate, and stir to react. The time is 5 minutes, so that the surface of the carbon rod is evenly covered with a layer of silver, the thickness of the silver layer is 0.5 μm, and then washed with water, and set aside.

[0026] The carbon rod whose surface is uniformly covered with silver layer is used as the carrier of the source core of radioactive particles, and deposited on its surface 125 I, after the reaction is completed, measure its 125 The absorption of I was 8.9%.

[0027] The carbon rod whose surfac...

Embodiment 2

[0029] The steps and method are the same as in Example 1, the difference is that the diameter of the carbon rod is 0.4mm, the concentration of silver nitrate is 12mmol / L, the concentration of disodium edetate is 100mmol / L, and the concentration of ammonium hydroxide is 7.5mol / L L, the concentration of hydrazine hydrate is 20mmol / L, and the reaction time is 90min.

[0030] The carbon rod whose surface is uniformly covered with silver layer is used as the carrier of the source core of radioactive particles, and deposited on its surface 125 I, after the reaction is completed, measure its 125 The absorption of I was 7.8%.

[0031] The carbon rod whose surface is uniformly covered with silver layer is used as the carrier of the source core of radioactive particles, and deposited on its surface 103 Pd, measured after the reaction is complete 103 The absorption of Pd is 12.2%.

Embodiment 3

[0033] The steps and method are the same as in Example 1, the difference is that the diameter of the carbon rod is 0.5mm, the concentration of silver nitrate is 12mmol / L, the concentration of disodium edetate is 150mmol / L, and the concentration of ammonium hydroxide is 10mol / L , the concentration of hydrazine hydrate is 40mmol / L, and the reaction time is 60min.

[0034] The carbon rod whose surface is uniformly covered with silver layer is used as the carrier of the source core of radioactive particles, and deposited on its surface 125 I, after the reaction is completed, measure its 125 The absorption of I was 8.5%.

[0035] The carbon rod whose surface is uniformly covered with silver layer is used as the carrier of the source core of radioactive particles, and deposited on its surface 103 Pd, measured after the reaction is complete 103 The absorption of Pd is 13.3%.

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Abstract

The invention belongs to the technical field of medical configured products containing radioactive substances, and discloses a source-core carrier for radioactive particles, and a preparation process thereof. The carrier is a carrier rod with the surface thereof uniformly coated with a silver layer. The carrier rod is a carbon rod. The preparation process comprises the following steps of putting the carrier rod in a mixed solution of silver nitrate, disodium ethylenediamine tetraacetate, ammonium hydroxide and hydrazine hydrate; reacting with stirring so as to uniformly coat the surface of the carrier rod with a silver layer; and washing with water. The source-core carrier and the preparation process thereof have the advantages of simple preparation and high utilization rate of radioactive nuclides.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing radioactive substances, and in particular relates to a source core carrier of radioactive particles and a preparation process thereof. Background technique [0002] Malignant tumors have always been a major disease that threatens human health, and interstitial brachytherapy of tumors using radioactive particles is a new technology developed in recent decades. This technology uses the rays emitted during the decay of radionuclides to continuously irradiate the tumor site at close range to kill tumor cells and achieve the purpose of relieving and treating diseases. It has been widely used in the treatment of various solid tumors, such as prostate cancer, Breast cancer, liver cancer, ovarian cancer, brain tumor, orbital tumor, etc. This technology has the characteristics of low energy, low activity, short half-life, simple operation, easy protection, good safety, and low equ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/02A61K49/04A61K101/02
Inventor 崔海平李忠勇高惠波周棱张文辉韩连革金小海
Owner HTA CO LTD
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