Method for preparing radioactive <124>I ions

A radioactive and ionic technology, applied in the direction of iodine/hydrogen iodide, iodine, alkali metal iodide, etc., can solve the problems of low yield and low recovery rate, and achieve high yield, high recovery rate and improved recovery rate Effect

Active Publication Date: 2014-05-07
MITRO BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] For this reason, the technical problem to be solved by the present invention is to solve the preparation of radionuclide in the prior art 124 I yield

Method used

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  • Method for preparing radioactive &lt;124&gt;I ions

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Embodiment 1

[0055] The preparation radioactivity described in this embodiment 124 The method of I ion, concrete steps are as follows:

[0056] a. Take 5mg of aluminum oxide and add it to 90mg of refined tellurium powder, stir evenly at the same time, and then press it to a thickness of 50mg / cm 2 Tellurium target, spare;

[0057] b. Place the tellurium target prepared above on the cyclotron, and pass Te(p,n) 124 I irradiate for 2 hours, the intensity of the incident p-particle beam is 20 μA, the energy is 20 MeV, and the incident angle is 6°. At the same time, water is used to cool the tellurium target in the irradiation. After the irradiation, the tellurium target is placed and cooled for 6 hours;

[0058] c. Take the above-mentioned cooled tellurium target and place it in the quartz distillation tube of the retort device, and replace the air in the quartz distillation tube with dry helium gas with a purity of 99.995% at a pressure of 0.25 MPa and a flow rate of 1000 mL / min; At this ti...

Embodiment 2

[0060] The preparation radioactivity described in this embodiment 124 The method of I ion also comprises the step of preparing tellurium dioxide, and concrete steps are as follows:

[0061] A. Take 80mg of tellurium powder, add 40mL of 6M nitric acid solution to dissolve, and the abundance of tellurium is ≥99.0%;

[0062] B, adding liquefied ammonium hydroxide to the solution obtained in the above step A to neutralize to a pH of 6.5, then heating the solution to dryness;

[0063] C. Take 15 mL of concentrated hydrochloric acid with a concentration of 12M to redissolve the dried residue in the above steps;

[0064] D. Neutralize the redissolved solution to a pH of 6.5 with liquefied ammonium hydroxide again, then heat the solution until it is close to boiling, and add a 15% hexamethylene solution dropwise to the solution, Precipitate tellurium dioxide, let it stand overnight and then filter, take the solid and dry it at 150°C to obtain the tellurium dioxide.

[0065] The pre...

Embodiment 3

[0070] The preparation radioactivity described in this embodiment 124 The method of I ion, concrete steps are as follows:

[0071] a. Add 5mg of aluminum oxide to 100mg of refined tellurium dioxide powder, mix well, and press to a thickness of 55mg / cm 2 Tellurium target, spare;

[0072] b. Put the tellurium target prepared above in the cyclotron, and pass Te(p,n) 124 I was irradiated for 2.5h, and the intensity of the incident p-particle beam was 19μA, the energy was 19MeV, and the incident angle was 8 ° , while cooling the tellurium target in the irradiation with water, and place the tellurium target to cool for 5 hours after the irradiation;

[0073] c. Take the above-mentioned cooled tellurium target and place it in the quartz distillation tube of the dry distillation device, and replace the air in the quartz distillation tube with dry neon gas with a purity of 99.995% at a pressure of 0.3 MPa and a flow rate of 800 mL / min; At this time, the temperature of the quartz di...

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Abstract

The invention discloses a method for preparing radioactive <124>I ions. The preparation method comprises the following steps: a, taking aluminium oxide powder and tellurium dioxide powder in a mass ratio of 1:18-22, uniformly mixing the powder, and pressing the obtained mixture into a tellurium target with a thickness of 50-60 mg/cm<2>; b, placing the prepared tellurium target in a circular accelerator, and irradiating the tellurium target 2-3 h by Te (p, n) <124>I, wherein the incident p particle beam intensity is 18-20 mu A, the energy is 18.5-20 MeV, and the angle of incidence is 6-10 DEG; meanwhile, cooling the tellurium target by using water in the process of irradiating, and after the irradiating is completed, placing the tellurium target to cool 4-6 h; c, placing the tellurium target in a quartz distillation tube of a destructive distillation device to distill, meanwhile, controlling the temperature to 750 DEG C so as to heat the tellurium target, so that radioactive <124>I ions are escaped, and collecting the radioactive <124>I ions. The problems that radionuclide <124>I prepared in the prior art is low in yield and low in recovery rate are solved.

Description

technical field [0001] The invention belongs to the field of preparation of radionuclides, in particular to a method for preparing radioactive nuclides 124 Ion method. Background technique [0002] Iodine can form stable compounds with various biomolecules such as proteins, nucleic acids, and amino acids. Due to its excellent nuclear and chemical properties, radioactive iodine has become second only to 99m Radionuclide of Tc. [0003] Radioactive iodine has been used to treat hyperthyroidism for more than half a century, and it is currently considered a safe treatment. In the United States, radioactive iodine therapy has become the most common method for the treatment of hyperthyroidism. About 70% of patients choose radioactive iodine therapy. It is suitable for patients who are older, ineffective or allergic to drugs, have heart disease or are otherwise not suitable for surgical treatment. In addition, radioactive iodine-labeled drugs have also become the most importan...

Claims

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Application Information

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IPC IPC(8): C01B7/14C01D3/12
Inventor 李新平虞善友徐建锋刘婷婷程亮崔夫新
Owner MITRO BIOTECH CO LTD
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