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Method for preparing geniposidic acid in eucommia leaf

A technology of genipinic acid and pinylic acid, which is applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of low product purity, low extraction rate, and large amount of waste water, and achieve membrane The effect of long time flux, low water extraction temperature and energy saving

Inactive Publication Date: 2015-04-22
HUBEI LAOLONGDONG DUZHONG DEV
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Problems solved by technology

[0004] In order to overcome the above-mentioned problems and shortcomings in the prior art, the present invention provides a method for preparing geniposidic acid from leaves of Eucommia ulmoides, the method is to add cellulase and Chinese The geniposide in Eucommia ulmoides leaves was extracted with warm water, and the extracted geniposide was separated and purified by two-stage membrane separation technology combined with resin adsorption and elution technology, and the ethanol eluate was collected, concentrated under reduced pressure, and dried in vacuum to obtain The product, geniposide, effectively solved the problems of low extraction rate, large amount of waste water and low product purity in the original production of geniposide

Method used

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  • Method for preparing geniposidic acid in eucommia leaf

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Embodiment Construction

[0024] Example 1, see the attached figure 1 , take 10Kg of dried Eucommia leaves, crush them and pass through 80 mesh sieve, add 120Kg of water, adjust the temperature to 55°C, keep the temperature constant and adjust the pH value to 4.5, then add 10g of cellulase, extract for 60min under this condition, filter, and filter the residue again Extract for the second time according to the aforementioned extraction conditions, combine the two filtrates, and filter conventionally, the extraction rate of geniposidic acid is 95.8%; the operating conditions are P=0.3Mpa, T=45°C, PH=4.5, Q=70L / The filtrate was passed through a 0.03μm ultrafiltration membrane, and the extract was concentrated by 11.2 times under this condition. The average flux of the ultrafiltration membrane was 226.3L / m 2 h; under the operating conditions P=1.5Mpa, T=50°C, PH=4.5, Q=20L / min, the ultrafiltration filtrate is passed through a 200 molecular weight nanofiltration membrane, and the ultrafiltration filtrate ...

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Abstract

The invention discloses a method for preparing geniposidic acid in eucommia leaf. The method is as below: crushing the eucommia leaves, extracting with warm water under assistance of cellulase, carrying out conventional filtration, removing impurities by an ultrafiltration membrane, concentrating by nanofiltration, separating and purifying by macroporous resin, concentrating and drying to obtain a geniposidic acid powder. The method uses cellulose-assisted warm water extraction of geniposidic acid in eucommia leaf, reaches an extraction rate of 95%, and has low water extraction temperature and short extraction time; ultrafiltration membrane is adopted to purification of the extract and separation of other by-products, and has the advantages of simple membrane operation process, stable membrane flux for a long time, easiness for cleaning, long service life and realization of industrialization; nanofiltration membrane is employed for concentrating the extract with impurities removed, so as to reduce the load of subsequent process and lengthen the service life of resins; the nanofiltration filtrate has a COD value of no more than 100, can be reused in the production process, and has no waste water discharge; and macroporous adsorption resin can effectively purify the geniposidic acid, so that the prepared powder contains geniposidic acid with purity greater than 60% and extraction rate of higher than 2.5%.

Description

technical field [0001] The invention relates to a method for preparing geniposide from leaves of eucommia ulmoides, in particular to a method for preparing geniposide by enzymatic medium-warm water extraction, membrane separation technology and resin technology. Background technique [0002] Geniposide is an important biologically active substance, which has many pharmacological effects such as protecting the liver and gallbladder, antihypertensive, protecting nerve cells, anti-inflammation, anti-tumor, anti-thrombosis, and inhibiting osteoporosis. It is widely used in the field of health care products. Geniposide is mainly found in natural plants such as eucommia and gardenia. Eucommia ulmoides is a unique economic tree species in my country, with a large distribution area and rich resources. The content of geniposide in Eucommia leaves is 1-4%, which is an ideal raw material for extracting geniposide. The problems of low extraction rate, low product purity, large energy c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08
Inventor 刘冬成任治军刘芸芳
Owner HUBEI LAOLONGDONG DUZHONG DEV
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