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Chuanxiong tea preparation

A Chuanxiong tea preparation, the technology of Chuanxiong, applied in anti-inflammatory agents, non-central analgesics, medical preparations of non-active ingredients, etc.

Inactive Publication Date: 2016-08-24
李兴惠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For oral solid preparations, drug stability is usually considered from two aspects: physical stability and chemical stability. As a pharmaceutical preparation such as granules, its physical stability is usually easier to meet the requirements of general pharmaceutical preparations, but for chemical stability However, those skilled in the art are often challenged

Method used

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  • Chuanxiong tea preparation
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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0107] Preparation of reference substance solution: Take an appropriate amount of ferulic acid reference substance, weigh it accurately, add 45% ethanol-glacial acetic acid (20:1) mixed solution to make a solution containing 10 μg per 1 ml, and obtain it.

[0108] Preparation of the test solution: Take the product under the difference in loading amount, grind it finely, take about 1.5g, accurately weigh it, add 25ml of 45% ethanol-glacial acetic acid (20:1) mixed solution, weigh it, Heat and reflux for extraction for 30 minutes, let cool, weigh again, make up the lost weight with 45% ethanol-glacial acetic acid (20:1) mixed solution, shake well, centrifuge (4000 rpm) for 10 minutes, and take the supernatant Liquid, that is.

[0109] Determination method: Precisely draw 10 μl each of the reference substance solution and the test solution, inject it into the liquid chromatograph, measure it, and obtain it.

[0110] Generally speaking, each bag of this product is required to con...

preparation example 1

[0120] Composition of raw materials:

[0121]

[0122] Preparation method:

[0123] (a) Add the water extracts of Chuanxiong, Angelica dahurica, Notopterygium, Licorice, Fangfeng, and Asarum to decoct twice, add 8 times the amount of water for the first time, decoct for 1.5 hours, and add 6 times for the second time Measure the water, decoct for 1 hour, filter the decoction, combine the filtrates, and obtain the water extract;

[0124] (b) adding 8 times the amount of water to both Peppermint and Schizonepeta, and extracting the volatile oil by steam distillation for 2.5 hours to obtain two parts of volatile oil and water extract (filtered);

[0125] (c) Combine the water extract obtained in step (a) with the water extract obtained in step (b), add 10 parts by weight of maltodextrin, concentrate to an extract with a relative density of 1.12-1.16 (80°C), and spray dry (air inlet temperature 230 ℃, air outlet temperature 110 ℃), obtain extract powder;

[0126] (d) adding t...

preparation example 2

[0141] Composition of raw materials:

[0142]

[0143]

[0144] Preparation method: basically the same as Preparation Example 1, but 7.5 parts by weight of maltodextrin are used in step (c), and lactose and dextrin are used in a weight ratio of 1:0.5 in step (d) and an appropriate amount is added to make the material The total weight amounts to 375 parts by weight. The obtained sample is designated as Ex2. The glycyrrhizic acid yield of the granule preparation sample obtained in this preparation example was measured with reference to the glycyrrhizic acid yield assay method in Preparation Example 1 to be 98.7%. Referring to the glycyrrhizic acid stability assay method in Preparation Example 1, the glycyrrhizic acid residual rate of the granule preparation sample obtained in this preparation example after high temperature treatment was determined to be 98.1%. The dissolution rate of the granule preparation sample obtained in this preparation example after high temperatu...

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Abstract

The invention relates to a ligusticum wallichii tea preparation. The ligusticum wallichii tea preparation is prepared by following medicinal materials including ligusticum wallichii, angelica dahurica, notopterygium roots, licorice roots, divaricate saposhnikovia roots, asarum, peppermint and schizonepeta. The invention further relates to a preparation method of the ligusticum wallichii tea preparation. The ligusticum wallichii tea preparation can be used for dispelling mild wind and relieving pain or can treat wind pathogen and headache or aversion to cold, fever and nasal obstruction.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a Chuanxiong tea preparation, especially a Chuanxiong tea preparation, and a preparation method of the Chuanxiong tea preparation. Background technique [0002] The original prescription of Chuanxiong Chatiao Granules comes from the "Taiping Huimin Heji Bureau Prescription" of the Song Dynasty. It has the effect of dispelling wind and relieving pain. It is used for headache due to wind pathogens, or aversion to cold, fever, and nasal congestion. This prescription is mainly composed of Chuanxiong, Nepeta, Fangfeng, Asarum, Angelica dahurica, Notopterygium, Peppermint, and Licorice (see, Lin Xiaolan. Analysis of the clinical application of Chuanxiong Chatiao Granules [J]. Beijing Traditional Chinese Medicine, 2004, 23(3): 190 -192), its curative effect is definite. It is believed that Chuanxiong Chatiao Granules have anti-platelet aggregation, relieve spasm of s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/538A61K47/36A61P29/00A61P25/06A61P11/02A61P11/00A61P9/10A61P7/02
Inventor 方东升徐建平陈君群徐少清陈有湖
Owner 李兴惠