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Dental and oral formulation containing protease and preparation method thereof

A technology of protease and stomatology, applied in the medical field, can solve the problems of high irritation, slow release of chlorine by hydrolysis, poor stability, etc.

Active Publication Date: 2014-05-21
武汉伢典生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 5. Chloramine-T (also known as chloramine) is easily soluble in water, and can be hydrolyzed to release chlorine under acidic conditions, which has certain oxidizing and bactericidal effects; but under neutral and alkaline conditions, its aqueous solution is very Stable, releases chlorine very slowly by hydrolysis
Using chloramine-T instead of sodium hypochlorite to prepare caries removal or root canal irrigation reagents can overcome the disadvantage of poor stability of sodium hypochlorite
Chloramine-T (chloryamine) has also been tried clinically as a root canal irrigation reagent, but its cytotoxicity is strong and irritating (cytotoxicity of root canal irrigation sodium hypochlorite and chloryamine, Zou Xiaoying, Yue Lin , Journal of Practical Stomatology, 2009, 25 (4): 572~575), not widely used clinically

Method used

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  • Dental and oral formulation containing protease and preparation method thereof
  • Dental and oral formulation containing protease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment １

[0043] Example 1: Dental root canal irrigation solution

[0044] Dissolve 200g of chloramine-T, 100g of pepsin and 100g of trypsin in 900ml of distilled water, add 1g of edible erythrosin to dissolve, adjust the pH value to 7.8 with 5% (w / v) potassium hydroxide solution, and add distilled water to 1000ml, after mixing, pack in colorless transparent plastic tube, each filled with 10ml.

Embodiment 2

[0045] Embodiment 2: dental anti-rot gel

[0046] Dissolve 20g of chloramine-T and 100g of pepsin in 900ml of distilled water, add 1g of edible erythrosin and 1g of food essence to dissolve, adjust the pH value to 7.0 with 5% (w / v) sodium phosphate solution, add carboxymethyl After stirring and dissolving 20g of sodium cellulose, add distilled water to 1000ml, mix well, and pack in colorless transparent plastic tubes, each filled with 10ml.

Embodiment 3

[0047] Example 3: Dental Root Canal Irrigation Solution

[0048] Dissolve 1 g of chloramine-T and 5 g of trypsin in 900 ml of distilled water, add 0.1 g of the pigment toluidine blue to dissolve, adjust the pH value to 11.4 with 5% (w / v) sodium hydroxide solution, add distilled water to 1000 ml, and mix well Finally, it is packaged in a colorless transparent plastic tube, each filled with 10ml.

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Abstract

The invention relates to the technical field of medical care, and provides a dental and oral formulation containing protease and a preparation method thereof. The main components of the formulation are chloramine-T and protease, and can be used in root canal flushing or decay removing of decayed teeth, dental whitening and small oral ulcer treatment and the like.

Description

technical field [0001] The invention relates to the field of medical technology, and relates to a protease-containing dental and stomatology preparation and a preparation method thereof. The preparation can be used for root canal irrigation, caries removal, dental whitening, and treatment of small oral ulcers. Background technique [0002] 1. Dental caries is listed by the World Health Organization (WHO) as one of the three major chronic non-communicable diseases that endanger human health, and it is also a common and frequently-occurring disease in children; while bacterial infection is the main incidence of pulp disease and periapical disease Among them, Gram anaerobic bacteria are the main pathogenic bacteria, and the detection rate is as high as 98.33%. [0003] The treatment of dental caries is mainly completed through several steps such as rot removal, sterilization, and filling. Among them, there are two methods of bur removal and chemical mechanical rot removal. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/66A61K8/04A61K8/02A61K38/48A61K9/08A61K9/06A61Q11/00A61P1/02
Inventor 岳力群黄安振吴伊雯
Owner 武汉伢典生物科技有限公司
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