Silymarin softgel, and preparation method and use thereof

A technology for silymarin and soft capsules is applied in the fields of silymarin soft capsules and their preparation and application, which can solve the problems of aggravating the burden on the liver of hepatitis patients and affecting the efficacy of medicine, and achieve the effects of good patient compliance, lightening the burden and definite curative effect.

Inactive Publication Date: 2014-06-04
QINGDAO BAICAOHUI INST OF CHINESE HERBAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For traditional Chinese medicine ingredients, the diluent commonly used to prepare soft capsules is vegetable oil, and silymarin is a drug for hepatitis. If vegetable oil (fat) is used as a diluent, it will increase the burden on the liver of hepatitis patients and affect the efficacy of the drug. The selection of diluent and how to improve the efficacy have become difficult problems in the preparation of silymarin soft capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: prepare soft capsule

[0021] Prescription composition (400mg / capsule):

[0022] components Quantity (g / 1000 capsules) Silymarin 400 PEG400 256.8

[0023] C. Preparation of soft capsules: Weigh gelatin and add it to a 100L gelatin reaction tank, add appropriate amount of water in the stirring state, seal it tightly, after the gelatin is completely dissolved, add glycerin, stir evenly, vacuumize and degas for 2 hours, and put it in a gelatin insulation bucket , keep it warm overnight, and set aside; weigh 400g of silymarin, mix it with PEG400, grind it with a colloid mill, and let it stand at room temperature. Put the prepared medicinal solution in the medicine hopper, and press the soft capsule with a mold. Adjust the volume of the soft capsules to the design range, dry them at room temperature for two days, remove the capsules with poor appearance quality, wash the capsules (remove the lubricating oil in the pellet pressing pr...

Embodiment 2

[0025] Embodiment 2: prepare soft capsule (400mg / grain)

[0026] components Quantity (g / 1000 capsules) Silymarin 400 PEG600 233

[0027] The prescription is composed as above, and others are the same as in Example 1.

[0028]

Embodiment 3

[0029] Embodiment 3: prepare soft capsule (650mg / grain)

[0030] components Quantity (g / 1000 capsules) Silymarin 650 polyethylene glycol 400 421.8

[0031] The prescription is composed as above, and others are the same as in Example 1.

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PUM

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Abstract

The invention provides a silymarin softgel and a preparation method thereof, and also provides an application of the softgel in the preparation of medicines for treating icteric hepatitis, acute and chronic hepatitis, metastatic hepatitis, and the ABO hemolytic disease and serious hepatitis of the newborn. The softgel has the advantages of no flavoring or antiseptic, good mouthfeel, easy administration, and stable and uniform content.

Description

[0001] Summary [0002] The invention provides a silymarin soft capsule and a preparation method thereof, and also provides an application of the soft capsule in preparing medicines for treating icteric hepatitis, acute and chronic hepatitis, persistent hepatitis, neonatal ABO hemolytic jaundice and severe hepatitis. The soft capsule provided by the invention does not contain flavoring agents and preservatives, has good taste and is easy to take, and has stable and uniform contents. technical field [0003] The invention relates to a silymarin soft capsule, a preparation method and application thereof. Background technique [0004] Milk thistle is the fruit of milk thistle, a plant of Compositae. In the late 1960s, German pharmacist H. Wagner and others discovered that milk thistle fruit contains silymarin, which can protect liver cell membranes and improve liver function. At present, milk thistle has become a worldwide hepatoprotective plant, and preparations based on it h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/357A61P1/16A61P31/14A61P31/20
Inventor 毕玉轩
Owner QINGDAO BAICAOHUI INST OF CHINESE HERBAL MEDICINE
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