Method for rapid detection of illegally added sibutramine in products

Abstract

The invention relates to a method used for rapid detection of illegal additives in weight-reducing medicines, health care products, or foods, and specifically relates to a method used for determining whether a product, which is suspected to be mixed with sibutramine, contains sibutramine. The method comprises following steps: (1) an appropriate amount of the product is collected, is mixed with a special solvent, and an obtained mixture is subjected to shaking or ultrasonic assisted dissolving so as to obtain a mixed liquid; (2) specific electrochemical parameters of the mixed liquid are determined using an appropriate detector based on specific electrochemical principles; and (3) illegal addition of sibutramine of the product can be determined based on the value of the electrochemical parameters. According to the method, filtration of sample solution is not needed; time consuming of the whole detection processes ranges from 2 to 3min; the method is rapid, convenient, and safe, is high in sensitivity, and is friendly to the environment.

Description

technical field [0001] The invention relates to the technical field of analysis of medicines, health food or food, in particular to a method for quickly screening illegally added sibutramine in medicine, health food or food based on electrochemical principles. Background technique [0002] Sibutramine is a 5-tryptamine and norepinephrine reuptake inhibitor listed by Knoll in 1997. Its chemical name is N-{1-[1-(4-chlorophenyl)cyclidine Base]-3-methylbutyl}-N,N'-dimethylamine, there is a chiral carbon atom in the molecular structure, which can act on the central nervous system, speed up metabolism, suppress appetite, increase satiety, and promote energy in the body Consumption, lower blood lipid levels and cholesterol levels, clinically used for the treatment of obesity, has the characteristics of good absorption and definite curative effect. After sibutramine hydrochloride went on the market, about 10 million people have used this product successively, and its sales have als...

AI Technical Summary

Problems solved by technology

Then, is it possible to directly use the electrochemical method of detecting the conductivity or total dissolved solids in water to detect weight loss drugs, health products or foods suspected of adding sibutramine? It was found that the effect was not ideal, because the complex matrix of weight-loss drugs, health care products or food that may add sibutramine contains other hydrophilic substances, which will seriously interfere with the conductivity of the sample solution and the total volume of the solution. Dissolved solids (TDS), resulting in no correlation with whether sibutramine was added

Therefore, it is technically difficult to directly detect whether sibutramine is illegally added to weight loss drugs, health products or food by electrochemical methods that detect the conductivity or total dissolved solids in the solution.

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