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Method for rapid detection of promethazines in products

A product, promethazine technology, applied in the preparation of test samples, electrochemical variables of materials, etc., can solve problems such as unsatisfactory effect, technical difficulties of promethazine substances, interference with sample solution conductivity, total dissolved solids, etc.

Active Publication Date: 2016-08-24
BEIJING INST FOR DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Then, is it possible to directly use the electrochemical method of detecting the conductivity or total dissolved solids in water to detect the central nervous system depressant drugs, health products or foods suspected of adding promethazine substances? It was found that the effect was not ideal, because the complex matrix of central nervous system depressant drugs, health care products or food that may be added with promethazines contains other hydrophilic substances, which will seriously interfere with the conductivity of the sample solution and in the solution. Total Dissolved Solids (TDS) of the total dissolved solids (TDS), resulting in no correlation between the results and the addition of promethazines
Therefore, it is technically difficult to directly use the electrochemical method of detecting the conductivity or total dissolved solids in the solution to detect whether the central nervous system depressant drugs, health products or food are illegally added with promethazines.

Method used

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  • Method for rapid detection of promethazines in products
  • Method for rapid detection of promethazines in products
  • Method for rapid detection of promethazines in products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1. General operating conditions for testing whether medicines / health products contain promazine substances

[0061] 1. Sampling amount:

[0062] The recommended sampling for different types of samples is as follows:

[0063] Sample type

Sample size

tablet

One oral dose (must be crushed)

Capsules

One oral dose (take the contents and grind)

Daimiwan

One oral dose (must be crushed)

Granules

One oral dose (must be crushed)

Other solids

One oral dose

[0064] It can be seen that the method of the present invention uses a small amount of the product to be inspected, so as to minimize the damage to the interests of innocent operators. The above various types of samples are taken at a time of about 0.5-5g, such as capsules and tablets. 0.5g, and the one-time dosage of granules and big honey pills is about 5g.

[0065] 2. Preparation of test solution

[0066] Take medicine, health food or food, add 20ml of 90% ethanol, add 2g of benzoic acid and shake for 1 m...

Embodiment 2

[0070] Example 2. General operating conditions for detecting whether medicines / health products contain promazine substances

[0071] 1. Sampling amount:

[0072] The recommended sampling for different types of samples is as follows:

[0073] Sample type

Sample size

tablet

One oral dose (must be crushed)

Capsules

One oral dose (take the contents and grind)

Daimiwan

One oral dose (must be crushed)

Granules

One oral dose (must be crushed)

Other solids

One oral dose

[0074] It can be seen that the method of the present invention uses a small amount of products to be inspected, so as to minimize the damage to the interests of innocent operators.

[0075] 2. Preparation of test solution

[0076] Take medicine, health food or food, add 20ml of 90% ethanol, add 2g of benzoic acid, and shake for 1 minute.

[0077] 3. Measure and judge the result

[0078] It is determined by an electrochemical method-based analyzer. When a conductivity detector is used to measure the sample s...

Embodiment 3

[0079] Example 3. Test for detecting whether there are promazine substances in medicines, health foods and foods

[0080] The method of Example 1 was used to quickly detect 20 batches of samples (all samples were sampled by the drug regulatory authority). In addition, in accordance with the "2010 Chinese Pharmacopoeia Standards", the HPLC method is used to test samples to verify the screening results.

[0081] The HPLC detection method recorded in the 2010 Chinese Pharmacopoeia standard is as follows:

[0082] Chromatographic column: octyl silane bonded silica gel as a packed column

[0083] Detection wavelength: 254nm;

[0084] Mobile phase: acetonitrile-trifluoroacetic acid;

[0085] Temperature: room temperature 23℃;

[0086] Flow rate: 1.0ml / min; injection volume: 5μl.

[0087] According to the following table, take a single oral dose of various solid samples, add 20ml of 90% ethanol, add 2g of benzoic acid, and shake for 1 minute. Then use an electrochemical method-based analyzer t...

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Abstract

The invention relates to a method for rapidly detecting promethazine substances in products. It specifically relates to a method for detecting whether a promethazine-like substance is contained in a product suspected of being mixed with a promethazine-like substance. The method comprises the following steps: (1) taking an appropriate amount of the product, mixing it with a special solvent, shaking or ultrasonically assisting dissolution, (2) Use an appropriate detector based on a specific electrochemical method to measure the specific electrochemical parameters of the mixed test solution; (3) According to the value of the parameter, it can be judged whether promethazines may be illegally added to the product Substance CNS depressant substance. The method of the invention does not need to filter the sample solution, and the whole detection process only takes 2 to 3 minutes, and has the advantages of fastness, simplicity, safety, high sensitivity, environmental protection and the like.

Description

Technical field [0001] The invention relates to the technical field of analysis of medicines, health foods or foods, in particular to a method based on electrochemical methods for quickly screening drugs, health foods or foods illegally added promazine central nerve inhibitors. Background technique [0002] Promazine compounds have inhibitory effects on the central nervous system. Its representative compound promethazine hydrochloride can block the H1 receptors in smooth muscles, capillary walls and other tissues, thereby having a competitive antagonistic effect with histamine. It can still have a significant central stabilizing effect, and can strengthen anesthetics, hypnotics and tranquilizers. The effect of pain. And can reduce body temperature and relieve vomiting. Another representative compound, chlorpromazine hydrochloride, has a stabilizing effect on the central nervous system. Small doses have antipsychotic effects. Continuous use of large doses has antipsychotic effec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/28G01N27/26
Inventor 王铁松车宝泉纪菁
Owner BEIJING INST FOR DRUG CONTROL
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