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Dicranostigma leptopodum berberrubine salt derivative

A kind of bald acne flower and compound technology, which is applied in the field of bald red alkali organic acid salt and its pharmaceutical application, can solve the problems of adverse reactions, drug resistance, and unsatisfactory therapeutic effect, and achieve the effect of practical therapeutic activity

Inactive Publication Date: 2014-06-18
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs for the treatment of cancer, these existing drugs are likely to cause multiple and severe adverse reactions, and some produce drug resistance, and the therapeutic effect of the existing drugs is still not ideal.

Method used

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  • Dicranostigma leptopodum berberrubine salt derivative
  • Dicranostigma leptopodum berberrubine salt derivative
  • Dicranostigma leptopodum berberrubine salt derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Alopecia erythrine fumarate

[0048] Dissolve 3.54 g (0.01 mol) of the compound alopecia rhodophylline and 1.17 g (0.01 mol) of fumaric acid in 95 ml of boiling ethanol. The hot solution is filtered through diatomaceous earth, then slowly cooled under gentle stirring, and left to stand for several hours in a temperature environment of 0-5°C, and the crystals of alopecia fumarate are precipitated, and the alopecia fumarate is filtered out Salt crystals were washed with ethanol and dried under vacuum at 50°C to obtain 4.69 g of product.

Embodiment 2

[0050] Alopecia erythrine fumarate

[0051] Stir 3.54 g of the compound alopecia fumarate and 1.17 g of fumaric acid in 95 ml of refluxing ethanol until all the solids are dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool down to room temperature while stirring. Standing for several hours in a temperature environment of 0-5°C, the crystals of alopecia redine fumarate are precipitated, the crystals of alopecia fumarate are filtered out, washed with ethanol and dried under vacuum at 50°C to obtain 4.68 g of product.

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Abstract

The invention relates to dicranostigma leptopodum berberrubine, a dicranostigma leptopodum berberrubine fumarate derivative, pharmaceutically acceptable solvates of the fumarate derivative, and applications of the solvates and the fumarate derivative for preparation of medicines treating cancer.

Description

field of invention [0001] The invention relates to the field of medicinal chemistry, in particular, the invention relates to an organic acid salt of alopecia rhizoid and its pharmaceutical application. Background technique [0002] For now, although there are many kinds of drugs for treating cancer, these existing drugs are likely to cause multiple and severe adverse reactions, and some produce drug resistance, and the therapeutic effect of the existing drugs is still not ideal. Chinese invention patent application publication number CN 102464617A describes some active compounds for treating cancer. Contents of the invention [0003] The present invention discloses some new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds and pharmaceutical applications of these compounds and compositions. [0004] These compounds exhibit good water solubility stability and solid form stability. Some of these compounds exhibit exce...

Claims

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Application Information

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IPC IPC(8): C07D221/18A61K31/473A61P35/00
CPCC07D221/18
Inventor 不公告发明人
Owner SHANGHAI YIZHI MEDICAL TECH
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