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Drug for treating renal-deficiency humid-heat type chronic nephritis

A technology for chronic nephritis and kidney deficiency damp-heat, which can be used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients. Obvious benefit and the effect of improving clinical syndromes

Active Publication Date: 2014-07-30
NANJING HOSPITAL OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, western medicine and western medicine mainly use hormones, immunosuppressants, ACEI / ARB drugs, etc. for the treatment of nephritis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take Astragalus 200g; Atractylodes macrocephala 120g; Cornus 80g Eucommia 300g; Alisma 100g;

[0027]a. Take Atractylodes macrocephala and Hedyotis diffusa to extract the volatile oil by steam distillation, soak in water with 6 times the weight of the medicinal material for 1 hour, distill for 8 hours to extract the volatile oil, add 6 times the weight of β-cyclodextrin to the volatile oil, and use a saturated aqueous solution Method 40 ℃ electric stirring, stirring speed of 120r / min, stirring for 1.5 hours after clathrate, clathrate 40 ℃ vacuum drying.

[0028] b. Take Astragalus, Eucommia, Alisma, Shiwei, Sanqiwuwei, and extract through ethanol reflux. The amount of alcohol added is 12 times the total weight of the decoction pieces, and the volume concentration of ethanol is 70%. Reflux extraction in three times, each time 2 hours, combined the extracts, filtered, and the filtrate recovered ethanol under reduced pressure, and concentrated until it had no alcohol smell...

Embodiment 2

[0032] Take Astragalus 400g; Atractylodes macrocephala 80g; Cornus 120g Eucommia 100g; Alisma 200g; Shiwei 100g; Hedyotis diffusa 300g;

[0033] a. Take Atractylodes macrocephala and Hedyotis diffusa to extract the volatile oil by steam distillation, soak in water with 6 times the weight of the medicinal material for 1 hour, distill for 8 hours to extract the volatile oil, add 6 times the weight of β-cyclodextrin to the volatile oil, and use a saturated aqueous solution Method 40 ℃ electric stirring, stirring speed of 120r / min, stirring for 1.5 hours after clathrate, clathrate 40 ℃ vacuum drying.

[0034] b. Take Astragalus, Eucommia, Alisma, Shiwei, Sanqiwuwei, and extract through ethanol reflux. The amount of alcohol added is 12 times the total weight of the decoction pieces, and the volume concentration of ethanol is 70%. Reflux extraction in three times, each time 2 hours, combined the extracts, filtered, and the filtrate recovered ethanol under reduced pressure, and conce...

Embodiment 3

[0038] Take Astragalus 300g; Atractylodes macrocephala 100g; Cornus 100g, Eucommia 200g; Alisma 150g; Shiwei 200g; Hedyotis diffusa 200g;

[0039] a. Take Atractylodes macrocephala and Hedyotis diffusa to extract the volatile oil by steam distillation, soak in water with 6 times the weight of the medicinal material for 1 hour, distill for 8 hours to extract the volatile oil, add 6 times the weight of β-cyclodextrin to the volatile oil, and use a saturated aqueous solution Method 40 ℃ electric stirring, stirring speed of 120r / min, stirring for 1.5 hours after clathrate, clathrate 40 ℃ vacuum drying.

[0040] b. Take Astragalus, Eucommia, Alisma, Shiwei, Sanqiwuwei, and extract through ethanol reflux. The amount of alcohol added is 12 times the total weight of the decoction pieces, and the volume concentration of ethanol is 70%. Reflux extraction in three times, each time 2 hours, combined the extracts, filtered, and the filtrate recovered ethanol under reduced pressure, and con...

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PUM

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Abstract

The invention discloses a drug for treating renal-deficiency humid-heat type chronic nephritis. The drug is prepared from the following material medicines in parts by weight: 20-40 parts of astragalus membranaceus, 8-12 parts of white atractylodes rhizome, 8-12 parts of pulp of dogwood fruit, 10-30 parts of eucommia ulmoides, 10-20 parts of rhizoma alismatis, 10-30 parts of herba pyrrosiae, 10-30 parts of oldenlandia diffusa and 3-7 parts of pseudo-ginseng. After being proved by a pharmacological experiment, the drug disclosed by the invention has a better function in treating chronic nephritis, is safe to take, suitable for preventing and treating chronic nephritis. The invention further discloses a preparation method and an application of the drug.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and more specifically relates to a traditional Chinese medicine formula medicine for treating chronic nephritis and its preparation method and application. Background technique [0002] Chronic nephritis is a common kidney disease with a high prevalence rate and a high mortality rate, and its incidence rate is increasing year by year. Chronic nephritis is caused by many reasons, and the pathological changes are different. Its main manifestations are edema, proteinuria, hematuria, high blood pressure and decreased renal function. In the ancient books of traditional Chinese medicine, there is no such disease name as "chronic glomerulonephritis". , but according to its clinical manifestations and onset characteristics, the disease belongs to the categories of "edema", "lumbar pain", "kidney wind", "diarrhea", "off grid", "kidney fatigue", "constipation", "constipati...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61P13/12
Inventor 谈瑄忠孔薇毛春芹陆兔林吴玥露杜秋
Owner NANJING HOSPITAL OF T C M
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