Traditional Chinese medicine granular suspension preparation for treating cough post influenza and cough variant asthma and preparation method thereof

A technology for variant asthma and traditional Chinese medicine granules, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., and can solve problems such as difficulty in taking patients.

Active Publication Date: 2014-08-20
北京东方运嘉科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Capsules are difficult for patients to take, not suitable for children, the elderly and those who have difficulty swallowing

Method used

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  • Traditional Chinese medicine granular suspension preparation for treating cough post influenza and cough variant asthma and preparation method thereof
  • Traditional Chinese medicine granular suspension preparation for treating cough post influenza and cough variant asthma and preparation method thereof
  • Traditional Chinese medicine granular suspension preparation for treating cough post influenza and cough variant asthma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] formula:

[0029] components

The proportion(%)

Weight (g / day)

Pharmaceutical active ingredient fine powder

15

3.0

DC Mannitol

63.36

12.68

corn starch

8.00

1.60

Western tragacanth

2.40

0.48

Tween 80

0.30

0.06

Stevioside

0.24

0.04

Sodium citrate

9.00

1.80

anhydrous citric acid

1.50

0.30

silica

0.20

0.04

total

100

20.0

[0030] 2) Preparation method

[0031] a. Add 0.075g of tragacanth gum into purified water to dissolve and prepare 0.05% tragacanth gum aqueous solution.

[0032] b. Add Tween 80, put it in the above aqueous solution and mix evenly to prepare a binding solution.

[0033] c. Mix Suhuang cough extract fine powder, direct-pressed mannitol, corn starch, remaining tragacanth gum, stevioside, sodium citrate, anhydrous citric acid and silicon dioxide and pass through a 65-mesh sieve.

[...

Embodiment 2

[0040] formula:

[0041] components

The proportion(%)

Weight (g / day)

Pharmaceutical active ingredient fine powder

30.0

6.0

DC Mannitol

40.0

8.0

corn starch

7.5

1.5

Western tragacanth

1.0

0.2

Tween 80

2.0

0.4

Stevioside

1.0

0.2

Sodium citrate

15.00

3.0

anhydrous citric acid

2.50

0.5

silica

1.0

0.2

total

100

20.0

[0042] 2) Preparation method

[0043] a. add tragacanth gum accounting for 1-10% of the weight of tragacanth gum into purified water to dissolve and prepare a 0.05% aqueous solution of tragacanth gum;

[0044] b. Add Tween 80 and mix in the above aqueous solution to prepare a binding solution;

[0045] c. Mix the active ingredient powder, direct-pressed mannitol, corn starch, remaining tragacanth gum, stevioside, sodium citrate, anhydrous citric acid and silicon dioxide and pass through a 65-...

Embodiment 3

[0052] formula:

[0053] components

[0054] The preparation method is the same as in Example 1.

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Abstract

The invention provides a traditional Chinese medicine granular suspension preparation for treating cough post influenza and cough variant asthma and a preparation method thereof. The traditional Chinese medicine granular suspension preparation comprises medicinal effective ingredients and pharmaceutically applicable medicinal adjuvants, wherein the medicinal effective ingredients are prepared from the following raw medicines in parts by weight by the conventional method: 4 to 6 parts of fried ephedra, 4 to 6 parts of folia perillae acutae, 4 to 6 parts of lumbricus, 4 to 6 parts of fried folium eriobotryae, 2 to 4 parts of perillaseed, 3 to 5 parts of periostracum cicada, 3 to 5 parts of radix peucedani, 4 to 6 parts of fructus arctii, and 3 to 5 parts of schisandra chinensis; the pharmaceutically applicable medicinal adjuvants include a filling agent, a diluent, an adhesive, a solubilizer, a cosolvent, an adsorbent and a corrigent. The traditional Chinese medicine granular suspension preparation integrates the advantages of liquid preparations and solid preparations, is quickly absorbed and fast to act after being orally taken, and is high in bioavailability, and convenient to carry and transport.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a Chinese medicinal particle suspension preparation for treating post-cold cough and cough variant asthma and a preparation method thereof. Background technique [0002] Cough variant asthma (Cough variant asthma, CVA), also known as insidious asthma or cough asthma, is a special type of asthma. Its particularity lies in the fact that it hardly has any symptoms of wheezing or dyspnea, so it is often missed, misdiagnosed, and mistreated. Many patients have been repeatedly and ineffectively used antibiotics and antitussive drugs for a long time, resulting in protracted aggravation of the condition. In recent years, with the gradual deepening of people's understanding of CVA, traditional Chinese medicine has achieved good results in the treatment of CVA. In traditional Chinese medicine writings, there is no disease name that exactly corr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/73A61K9/16A61P11/14A61P11/06
Inventor 晁恩祥晁燕曾风英
Owner 北京东方运嘉科技发展有限公司
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