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Coating auxiliary material, preparation method and coating method for traditional Chinese medicine extract preparation

An extract and coating technology, which is applied in the field of coating excipients of traditional Chinese medicine extract preparations, can solve the problem that the coating excipients cannot be used in different traditional Chinese medicine prescriptions, and achieve improved coating appearance, excellent barrier performance, and good coating force Effect

Active Publication Date: 2017-02-15
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a coating auxiliary material, preparation method and coating method for Chinese medicine extract preparations, so as to solve the problem that the above-mentioned existing coating auxiliary materials cannot be commonly used in different traditional Chinese medicine prescriptions

Method used

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  • Coating auxiliary material, preparation method and coating method for traditional Chinese medicine extract preparation
  • Coating auxiliary material, preparation method and coating method for traditional Chinese medicine extract preparation
  • Coating auxiliary material, preparation method and coating method for traditional Chinese medicine extract preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A coating auxiliary material for Chinese medicine extract preparations, comprising the following components by weight ratio: 15% of hydroxypropyl methylcellulose HPMC, 25% of propylene glycol, 25% of titanium dioxide, 30% of talcum powder and stearic acid Magnesium is 5%. The above reagents are fully mixed to prepare coating auxiliary materials.

[0027] The above-mentioned coating auxiliary material is used for the coating method of Chinese medicine extract preparation, comprises the following steps:

[0028] a. Weigh ethanol and purified water as solvents, pour them into a mixer and stir, the weight of ethanol is 0.5 times of the coating auxiliary materials, and the weight of purified water is 2.0 times of the coating auxiliary materials; add the coating auxiliary materials while stirring, and add them Then continue to stir for 30 minutes to obtain the coating solution, which is set aside;

[0029] B, start the coating machine, take the tablet, the weight of the coa...

Embodiment 2

[0033] A coating auxiliary material for Chinese medicine extract preparations, comprising the following components by weight ratio: 20% hydroxypropyl cellulose HPC, 20% glycerin, 57% talcum powder (30% coloring agent, 27% auxiliary additives), and magnesium stearate at 3%. The above reagents are fully mixed to prepare coating auxiliary materials.

[0034] The above-mentioned coating auxiliary material is used for the coating method of Chinese medicine extract preparation, comprises the following steps:

[0035] a. Weigh ethanol and purified water as solvents, pour them into a mixer and stir, the weight of ethanol is 1.0 times of the coating auxiliary materials, and the weight of purified water is 2.5 times of the coating auxiliary materials; add the coating auxiliary materials while stirring, and add them Then continue to stir for 40 minutes to obtain the coating solution, which is for subsequent use;

[0036]B, start the coating machine, take the tablet, the weight of the c...

Embodiment 3

[0040] A coating auxiliary material for Chinese medicine extract preparations, comprising the following components by weight ratio: 20% polyvinylpyrrolidone PVP, 25% triacetin glyceride, 20% color lake, 31% talcum powder and magnesium stearate 4%. The above reagents are fully mixed to prepare coating auxiliary materials.

[0041] The above-mentioned coating auxiliary material is used for the coating method of Chinese medicine extract preparation, comprises the following steps:

[0042] a. Weigh ethanol and purified water as solvents, pour them into a mixer and stir, the weight of ethanol is 0.5 times of the coating auxiliary materials, and the weight of purified water is 3.0 times of the coating auxiliary materials; add the coating auxiliary materials while stirring, and add them Then continue to stir for 60 minutes to obtain the coating solution, which is set aside;

[0043] b. Start the coating machine, weigh the tablets, and the weight of the coating auxiliary materials i...

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PUM

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Abstract

A coating auxiliary material for extract preparations of traditional Chinese medicines, the main components of which include by weight: 15-20% of film-forming agent, 20-25% of plasticizer, 20-30% of colorant and 30-35% of auxiliary additives . The invention also discloses a preparation method of a coating auxiliary material used for extract preparations of traditional Chinese medicines and a coating method. The coating powder of the invention has good coating power, can cover the defects of the tablet core, and improve the appearance of the coating; The coating film has excellent barrier properties, and its moisture-proof and taste-masking effects on pharmaceutical preparations are better than ordinary coating materials; the coating preparation disintegrates quickly and has no effect on the release of pharmaceutical ingredients.

Description

technical field [0001] The invention relates to the field of coating auxiliary materials, in particular to a coating auxiliary material for Chinese medicine extract preparations, a preparation method and a coating method. Background technique [0002] Most of the solid preparations of traditional Chinese medicine are extracted by water or ethanol in the preparation process. However, due to the complex composition of the medicinal materials, the extracts produced by this method are often rich in substances that are highly hygroscopic such as sugars, resins, and tannins. Softening, darker appearance, agglomeration, reduced fluidity and even mildew appear, which seriously affects the quality and curative effect of medicines, and brings great difficulties to the production and storage of medicines. For a long time, in the process of pharmaceutical preparations, solid granules or tablet cores are often coated, and film coating is used as a barrier to help isolate the dosage form ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K9/32A61K47/38A61K47/32A61K36/00
Inventor 周万辉曾英姿张丹赵磊于洪亮王冬梅程世娟
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD
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