Composition and application thereof in medicine

A composition and drug technology, applied in the field of medicine, can solve the problems of no prevention and treatment of diabetes, kidney disease, etc.

Active Publication Date: 2014-09-17
广州艾格生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the composition composed of rhein and berberine, and there is no report on the composition being used for the prevention and treatment of diabetes and nephropathy

Method used

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  • Composition and application thereof in medicine
  • Composition and application thereof in medicine
  • Composition and application thereof in medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]

[0018] Mix rhein, berberine, starch, microcrystalline cellulose, and povidone K30 in a rapid stirring granulator, add purified water to moisten the soft material, pass through 18-24 mesh to granulate, 40-70 Dry at ℃ until the weight loss on drying is less than 6%, granulate through 24-60 mesh, add magnesium stearate, mix evenly, and compress the granules after passing the inspection.

Embodiment 2

[0020]

[0021] Mix rhein, berberine, starch, microcrystalline cellulose, and povidone K30 in a rapid stirring granulator, add purified water to moisten the soft material, pass through 18-24 mesh to granulate, 40-70 Dry at ℃ until the weight loss on drying is less than 6%, granulate through 24-60 mesh, add magnesium stearate, mix evenly, and compress the granules after passing the inspection.

Embodiment 3

[0023]

[0024] Mix rhein, berberine, starch, microcrystalline cellulose, and povidone K30 in a rapid stirring granulator, add purified water to moisten the soft material, pass through 18-24 mesh to granulate, 40-70 Dry at ℃ until the weight loss on drying is less than 6%, granulate through 24-60 mesh, add magnesium stearate, mix evenly, and compress the granules after passing the inspection.

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Abstract

The invention relates to a composition mixed by parietic acid and berberine, and the composition is used for preventing and treating diabetes and nephropathy and belongs to the medicine field. The composition is characterized in that the mass ratio of parietic acid and berberine is (1:2)-(1:10). A large number of experiments prove that within the mass ratio of 1:2-1:10, the parietic acid and berberine have a synergic effect, and the parietic acid has no side effects like diarrhea, if the mass ratio is not within (1:2)-(1:10) (such as 1 or 2), the parietic acid and berberine have no synergic effect, so that the specific ratio is the key to the composition.

Description

technical field [0001] The invention relates to a composition composed of rhein and berberine, which is used for preventing and treating diabetes and nephropathy, and belongs to the field of medicine. Background technique [0002] Rhein, chemical name 1,8-dihydroxy-3-carboxyanthraquinone, molecular formula C 15 h 8 o 6 , It is coffee-colored needle crystal, which becomes yellow needle crystal after sublimation, insoluble in water, slightly soluble in ethanol, ether, benzene and acetone. Commonly used medicinal materials rhubarb, senna, and fleece-flower root all contain rhein, which is clinically used to treat diabetic nephropathy, diabetes and other diseases. However, rhein can easily cause diarrhea, which may be caused by its metabolite anthrone in the intestinal microbial system. In addition, the solubility of rhein is also relatively poor. Rhein is insoluble in water and alcohol, and insoluble in most organic solvents, and its bioavailability is low. Although diacet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A23L1/29A61P3/10A61P13/12A61K31/192A23L33/00
Inventor 张现涛徐勤何盛江徐茂宝谭斌
Owner 广州艾格生物科技有限公司
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