Polylactic acid (PLA) medicinal polymer with hexagonal columnar porous structure
A technology of polylactic acid and polymer materials, which is applied in the preparation of block polymer materials and the preparation of star-shaped block copolymer porous drug carriers, to achieve reduced toxic and side effects, high drug load, and good biocompatibility Effect
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[0022] Example 1:
[0023] ①Preparation of star block copolymer
[0024] Using L-lactide as the raw material, the three-arm or multi-arm star polylactic acid was synthesized by the classic stannous octoate catalyzed ring-opening method. Due to the presence of the hydroxyl group at the end of the polymer, it was in an ice bath with bromoisobutyryl bromide. In the middle reaction, the star-shaped macroinitiator SPLA-Br with bromine terminal functional group was obtained. The macroinitiator and NIPAM are subjected to ATRP polymerization in a certain proportion to obtain a star-shaped block polymer of PNIPAM with PLA as the core.
[0025] ②Characterization of the self-assembled structure and properties of star-shaped block copolymer materials
[0026] The chemical structure and morphological characteristics of polymers are the basis for studying various properties of polymers. This subject intends to use Gel Permeation Chromatography (GPC), Fourier Transform Infrared Spectroscopy (FTIR)...
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