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Novel medical polyethylene glycol (PEG) functional material

A technology of polyethylene glycol and functional materials, applied in the fields of polymer chemistry and polymers, to achieve the effect of reducing toxic and side effects

Inactive Publication Date: 2014-10-22
CHENGDU LVKE HUATONG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Through our review of literature, there is no polylactic acid material that has the characteristics of high processing performance, hydrophilicity, excellent biodegradability, nanoscale micropores, and high drug loading capacity.

Method used

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  • Novel medical polyethylene glycol (PEG) functional material
  • Novel medical polyethylene glycol (PEG) functional material
  • Novel medical polyethylene glycol (PEG) functional material

Examples

Experimental program
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Embodiment 1

[0025] ①Preparation of star block copolymer

[0026] Using ethylene oxide as raw material, three-arm or multi-arm star-shaped polyethylene glycol was synthesized by classic alkali method ring-opening. Due to the existence of hydroxyl groups at the end of the polymer, glycine protected by amino Boc-groups can be used. Under the catalysis of DCC / HOBt, it reacts with SPEG to generate SPEG derivatives. In trifluoroacetic acid / dichloromethane solution, the amino group of the above product is de-Boc-protected, and the star-shaped macromolecular initiator SPEG-NH with amino-terminated functional groups is obtained. 2 . The macroinitiator and O-tert-butyl-L-threonine carboxylic acid anhydride (NCA) are subjected to ring-opening polymerization in a certain ratio to obtain poly-O-tert-butyl-L-threonine with PEG as the core star block polymers.

[0027] ②Characterization of the self-assembled structure and properties of star-shaped block copolymer materials

[0028] The chemical struc...

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Abstract

The invention discloses a novel medical polyethylene glycol (PEG) functional material. A preparation method of the material comprises the following steps: with ethylene oxide as a raw material, synthesizing three-arm PEG by utilizing alkaline ring opening; preparing a macroinitiator; carrying out ring opening polymerization with O-tert-butyl-L-threonine carboxyl anhydride (NCA) to obtain a star-shaped block polymer with PEG as a kernel and poly(O-tert-butyl-L-threonine) as an arm; adding low molecular weight poly-threonine and dissolving low molecular weight poly-threonine with water by utilizing amphipathicity of a block copolymer to form the nanoscale porous material, wherein the block copolymer has a hexagonal prism shaped structure; the continuous phase is PEG; the material has nanoscale pores. The material has the advantages that the material has nanoscale micropores, overcomes the defect that traditional linear PEG materials have poor processability, does not have toxic or side effects and can serve as a medicine carrier material, a medical implant material and a part material of in vivo continuous administration devices.

Description

technical field [0001] The invention relates to a novel medical polyethylene glycol functional material, in particular to a preparation method of a block macromolecule material with nanoscale micropores. The invention belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Polylactic acid (PLA) is a new generation of fully degradable polymer materials developed rapidly in the 1990s. It has excellent biocompatibility and is approved by the US Food and Drug Administration (FDA). A class of biomedical materials and environmental protection materials. Since the 1960s, scientists began to pay attention to the degradation performance of polylactic acid materials, and for the first time used polylactic acid materials as degradable surgical suture materials. In 1966, Kulkarni et al. (Kricheldorf H. R. Chemosphere 2001, 43, 49-54. It was first proposed that low molecular weight PLA can be degraded in vivo, and the final metabolite is CO 2 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/26C08G69/40C08G65/333C08G65/28A61K47/34
Inventor 不公告发明人
Owner CHENGDU LVKE HUATONG TECH
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