Novel medical polyethylene glycol (PEG) functional material
A technology of polyethylene glycol and functional materials, applied in the fields of polymer chemistry and polymers, to achieve the effect of reducing toxic and side effects
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[0025] ①Preparation of star block copolymer
[0026] Using ethylene oxide as raw material, three-arm or multi-arm star-shaped polyethylene glycol was synthesized by classic alkali method ring-opening. Due to the existence of hydroxyl groups at the end of the polymer, glycine protected by amino Boc-groups can be used. Under the catalysis of DCC / HOBt, it reacts with SPEG to generate SPEG derivatives. In trifluoroacetic acid / dichloromethane solution, the amino group of the above product is de-Boc-protected, and the star-shaped macromolecular initiator SPEG-NH with amino-terminated functional groups is obtained. 2 . The macroinitiator and O-tert-butyl-L-threonine carboxylic acid anhydride (NCA) are subjected to ring-opening polymerization in a certain ratio to obtain poly-O-tert-butyl-L-threonine with PEG as the core star block polymers.
[0027] ②Characterization of the self-assembled structure and properties of star-shaped block copolymer materials
[0028] The chemical struc...
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