Method for preparing multicomponent multifunctional polylactic acid (PLA) drug carrier

Abstract

The invention discloses a method for preparing a multicomponent multifunctional polylactic acid (PLA) drug carrier. The method comprises the steps: synthesizing three-arm or multi-arm star-shaped polylactic acid (SPLA) from L-lactide, which serves as a raw material, by using a classical stannous octoate catalyzed ring opening method, and enabling SPLA to react with bromo-isobutyryl bromide in an ice bath due to the existence of terminal hydroxyl of the polymer, so as to obtain a star-shaped macromolecular initiator SPLA-Br with bromine-terminated functional groups; carrying out ring opening polymerization on the macromolecular initiator and HPA (Hydroxypropyl Acrylate) according to a certain ratio, so as to obtain a PHPA (Poly Hydroxypropyl Acrylate) star-shaped block polymer which takes PLA as a core, then, adding N-isopropylacrylamide, and carrying out ATRP (Atom Transfer Radical Polymerization) once again, so as to obtain a triblock copolymer; and adding PHPA with low molecular weight, and dissolving the block copolymer by using the amphiphilic nature of the block copolymer, thereby forming a nano-scale porous material. The block copolymer has a hexagonal columnar structure, and a continuous phase is PLA, so that the material is provided with nano-scale pores. The material has the following advantages that the material is provided with nano-scale micropores; the defect of the traditional linear PLA materials that the processability is poor is overcome; the material is free from toxic and side effects; the material can serve as a drug carrier material; the material can serve as a medical implant material; and the material can serve as a component material for in-vivo sustained medication devices.

Description

Technical field [0001] The invention relates to a preparation method of a polylactic acid derivative that can be used as a drug carrier, in particular to a preparation method of a block macromolecule material with nanoscale micropores. The invention belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Polylactic acid (PLA) is a new generation of fully degradable polymer materials developed rapidly in the 1990s. It has excellent biocompatibility and is approved by the US Food and Drug Administration (FDA). A class of biomedical materials and environmental protection materials. Since the 1960s, scientists began to pay attention to the degradation performance of polylactic acid materials, and for the first time used polylactic acid materials as degradable surgical suture materials. In 1966, Kulkarni et al. (Kricheldorf H. R. Chemosphere 2001, 43, 49-54. It was first proposed that low molecular weight PLA can be degraded in vivo, an...

AI Technical Summary

Problems solved by technology

Through our review of literature, there is no polylactic acid material that has the characteristics of high processing performance, hydrophilicity, excellent biodegradability, nanoscale micropores, and high drug loading capacity.

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