Preparation method of multifunctional medicinal polylactic acid (PLA) derivative ABC triblock polymer

A technology of polylactic acid and star-shaped copolymer is applied in the preparation of star-shaped block copolymer porous drug carriers and the preparation of block polymer materials, and achieves reduction of toxic side effects, high drug loading, and biocompatibility. Good results

Inactive Publication Date: 2014-09-24
CHENGDU LVKE HUATONG TECH
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Through our review of literature, there is no polylactic acid material that has the characteristics of high proces

Method used

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  • Preparation method of multifunctional medicinal polylactic acid (PLA) derivative ABC triblock polymer
  • Preparation method of multifunctional medicinal polylactic acid (PLA) derivative ABC triblock polymer
  • Preparation method of multifunctional medicinal polylactic acid (PLA) derivative ABC triblock polymer

Examples

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[0022] Example 1:

[0023] ①Preparation of star block copolymer

[0024] Using L-lactide as the raw material, the three-arm or multi-arm star polylactic acid was synthesized by the classic stannous octoate catalyzed ring-opening method. Due to the presence of the hydroxyl group at the end of the polymer, it was in an ice bath with bromoisobutyryl bromide. In the middle reaction, the star-shaped macroinitiator SPLA-Br with bromine terminal functional group was obtained. The macroinitiator and DMA are subjected to ATRP polymerization in a certain proportion to obtain a star-shaped block polymer with PLA as the core PDMA.

[0025] ②Characterization of the self-assembled structure and properties of star-shaped block copolymer materials

[0026] The chemical structure and morphological characteristics of polymers are the basis for studying various properties of polymers. This subject intends to use Gel Permeation Chromatography (GPC), Fourier Transform Infrared Spectroscopy (FTIR) and Nu...

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Abstract

The invention discloses a preparation method of a multifunctional medicinal polylactic acid (PLA) derivative ABC triblock polymer. The preparation method comprises the following steps of with L-lactide as a raw material, synthesizing three-arm or multi-arm star-shaped PLA by using a classical stannous octoate catalyzed ring-opening method, and due to the existence of hydroxyl at the terminal of a polymer, enabling three-arm or multi-arm star-shaped PLA to react with bromoisobutyryl bromide in ice bath to obtain a star-shaped macroinitiator SPLA-Br of a bromo-terminal functional group; carrying out ring opening polymerization on the macroinitiator and DMA (Dimethyl Adipate) according to a certain ratio to obtain a star-shaped PDMA (Poly(dimethyl acrylamide)) block polymer with PLA as a core, then, adding N-isopropylacrylamide, and carrying out ATRP (Atom Transfer Radical Polymerization) to obtain a triblock copolymer; adding PDMA with low-molecular weight, and dissolving the PDMA with water by means of the amphipathicity of the block copolymer to form a nanoporous material. The block copolymer is of a hexagonal prism shaped structure, contains PLA as a continuous phase and is provided with nano-grade micropores. The material has the following advantages that the material is provided with the nano-grade micropores; the defect of poor processability of the traditional linear PLA material is overcome; no toxic or side effect is generated; the material can be used as a drug carrier material, a medical implant material and an in-vivo continuous dosing device part material.

Description

Technical field [0001] The invention relates to a method for preparing a star-shaped block copolymer porous drug carrier, in particular to a method for preparing a block polymer material with nano-scale micropores. It belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Polylactic acid (PLA) is a new generation of fully degradable polymer materials that developed rapidly in the 1990s. It has excellent biocompatibility and is recognized by the Food and Drug Adiministration (FDA) A class of biomedical materials and environmental protection materials. Since the 1960s, scientists began to pay attention to the degradation properties of polylactic acid materials, and for the first time used polylactic acid materials as biodegradable surgical suture materials. In 1966, Kulkarni et al. (Kricheldorf H. R. Chemosphere 2001, 43, 49-54. It was first proposed that low molecular weight PLA can be degraded in the body, and the final metabolite is CO...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08F220/34C08F220/54C08F120/34C08J9/26A61K47/34
Inventor 不公告发明人
Owner CHENGDU LVKE HUATONG TECH
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