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Application of Arctigenin in the Preparation of Drugs for Treating Peptic Ulcer Diseases

A technology of arctigenin and diseases, which is applied in the field of medicine, can solve the problems of treating peptic ulcer diseases without arctigenin, achieve the effects of improving the treatment effect and quality of life, reducing the toxic and side effects of the human body, and reducing the ulcer index

Active Publication Date: 2018-03-20
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Arctigenin has significant antibacterial, antiviral, antitumor, and anti-PAF receptor effects, but there is no report of arctigenin treating peptic ulcer disease in the prior art

Method used

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  • Application of Arctigenin in the Preparation of Drugs for Treating Peptic Ulcer Diseases
  • Application of Arctigenin in the Preparation of Drugs for Treating Peptic Ulcer Diseases
  • Application of Arctigenin in the Preparation of Drugs for Treating Peptic Ulcer Diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 arctigenin injection

[0017]

[0018] Preparation process: Mix the prescribed amount of propylene glycol and ethanol evenly, add arctigenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain .

Embodiment 2

[0019] Embodiment 2 arctigenin injection

[0020]

[0021] Preparation process: Mix the prescribed amount of PEG-400 and ethanol evenly, add arctigenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for needles, stir, remove Charcoal, that is.

Embodiment 3

[0022] Embodiment 3 arctigenin injection

[0023]

[0024]

[0025]Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add arctigenin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

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Abstract

The invention belongs to the field of medicine and relates to the medical use of arctigenin, in particular to the use of arctigenin in the preparation of medicines for treating peptic ulcer diseases, preferably an injection preparation thereof. Studies have shown that arctigenin has inhibitory effects on water-immersion stress gastric ulcer in rats, pyloric ligation gastric ulcer, gastric ulcer induced by absolute ethanol in mice, and experimental duodenal ulcer in rats. Index; It has a significant inhibitory effect on acetic acid-induced ulcerative colitis in rats. When arctigenin is used in the treatment of peptic ulcer disease, it has the advantages of definite curative effect and low toxicity and side effects, so it has broad application prospects.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a medical application of arctigenin, in particular to the application of arctigenin in the preparation of medicines for treating peptic ulcer disease. Background technique [0002] The digestive system is composed of organs such as esophagus, gastrointestinal tract, liver, gallbladder and pancreas. Its main function is to digest and absorb food and provide material and energy sources for the body's metabolism. Because most of the organs it includes are in a highly acidic environment and the relative closure of the digestive system, digestive system diseases occur from time to time, and in recent years, due to the pressure of environmental pollution and the improvement of people's quality of life, the incidence of digestive system diseases has risen rapidly trend. According to statistics, the total incidence of digestive system diseases accounts for 30% of the population, and 1 / 2 of the out...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P1/04
Inventor 赵志全姚景春李春燕李晓梅苏勤勇
Owner SHANDONG NEWTIME PHARMA
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