Cefalexin capsule and preparation process thereof

The technology of cephalexin capsules and cephalexin is applied in the directions of capsule delivery, medical preparations without active ingredients, medical preparations containing active ingredients, etc. and other problems, to achieve the effects of less toxic and side effects, low polymer content, and good formulation stability.

Active Publication Date: 2014-11-05
ZHONGSHAN NIKEMEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the prior art fails to provide a cephalexin preparation with low polymer content, good stability, simple preparation process, and low toxic and side effects

Method used

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  • Cefalexin capsule and preparation process thereof
  • Cefalexin capsule and preparation process thereof
  • Cefalexin capsule and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029] Preparation process: cephalexin, polacrilin potassium IRP-88, and chitosan are passed through 80-mesh sieve respectively, and the prescription quantity is weighed to take cephalexin, polacrilin potassium IRP-88, and chitosan, add talcum powder and mix evenly, and fill the capsule , that is.

Embodiment 2

[0031]

[0032] Preparation process: cephalexin, polacrilin potassium IRP-88, and chitosan are respectively passed through a 80-mesh sieve, and the prescription amount is weighed to take cephalexin, polacrilin potassium IRP-88, and chitosan, and zinc stearate is added to mix evenly. Fill capsules and get ready.

Embodiment 3

[0034]

[0035] Preparation process: cephalexin, polacrilin potassium IRP-88, and chitosan are respectively passed through a 80-mesh sieve, and the prescription amount is weighed to take cephalexin, polacrilin potassium IRP-88, and chitosan, and zinc stearate is added to mix evenly. Fill capsules and get ready.

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PUM

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Abstract

The invention discloses a cefalexin capsule and a preparation process thereof. The capsule is formed by filling content in a capsule shell, wherein the content contains cefalexin, polacrilin potassium IRP-88 and chitosan. The cefalexin capsule prepared by the invention is low in high polymer content, high in preparation stability, simple in preparation process and small in toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a solid oral preparation of cephalexin, in particular to a capsule containing cephalexin. Background technique [0002] Cefalexin is a semi-synthetic oral cephalosporin antibiotic listed by Eli Lilly Company in the United States in 1970. Its chemical name is (6R, 7R)-3-methyl-7-[(R)-2-amino-2-phenylacetamido]- 8-Oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, the structural formula is as follows: [0003] [0004] Cephalexin is a derivative synthesized by chemically modifying the 7-amino group and the 3-position acetoxymethyl group of 7-ACA. It belongs to the first generation cephalosporin, which inhibits the synthesis of cell walls, causing the cell contents to swell to burst Dissolve, so as to achieve bactericidal effect. [0005] Cephalexin is suitable for most strains of Streptococcus pneumoniae, Streptococcus hemolyticus, Staph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/32A61K31/545A61P31/04
Inventor 孙丽华
Owner ZHONGSHAN NIKEMEI PHARMA
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