Cell preparation including fat cell

A cell preparation and adipocyte technology, applied in the field of cell preparation, can solve the problems of insufficient research and unknown cell effectiveness, and achieve the effects of promoting implantation efficiency and tissue regeneration efficiency, alleviating joint pain, and improving QOL

Inactive Publication Date: 2014-12-10
佐伯正典
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, transplantation of adipocytes and adipose-derived stem cells has been mostly used for regeneration of soft tissues so far, and the effectiveness of these cells in alleviating joint pain and tissue regeneration in joints, for example, has not been sufficiently studied.
In addition, it is not known about muscle repair by administering adipocytes and adipose stem cells to damaged muscles

Method used

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  • Cell preparation including fat cell
  • Cell preparation including fat cell
  • Cell preparation including fat cell

Examples

Experimental program
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Effect test

preparation example Construction

[0069] 2. Preparation method of cell preparation

[0070] In the present invention, adipocytes can be collected, separated and concentrated as necessary to prepare the cell preparation of the present invention. In addition, in the case of preparing a cell preparation containing adipocytes and mesoderm stem cells, materials collected as a mixture of these cells may be used, or the respective cells may be collected separately and then mixed to obtain the present invention. cell preparations. For example, when the mesodermal stem cells are adipose stem cells, since they can be prepared simultaneously from the same tissue as adipocytes and are simple, a mixture of adipocytes and adipose stem cells can be obtained from adipose tissue, and it is preferable to make the cell preparation of the present invention . In addition, more simply, adipose tissue containing these cells can also be used.

[0071] When preparing the cell preparation of the present invention from adipose tiss...

Embodiment

[0117] Preparation of Cell Preparations

[0118] For the preparation of the cell preparation, LIPOMAX-SC (manufactured by Medikan Corp., Seoul, Korea) kit was used. In the preparation process of the present cell preparation, it can be carried out without the cells being exposed to the atmosphere at all. The specific method is as follows.

[0119] (i) Each subject was subjected to liposuction using a syringe (syringe manufactured in LIPOMAX-SC: manufactured by Medikan Corp., Seoul, Korea). The syringe containing the collected fat was allowed to stand at room temperature (about 25° C.) for about 10 minutes, separated into a cell fraction and a liquid fraction, and the liquid fraction containing the swelling fluid was used as waste. The remaining cell fraction was used in Test Example 2 as adipose tissue. Then, the syringe was centrifuged at 2200 xg for 8 minutes. It was separated into three layers by centrifugation: an upper layer (free oil), an intermediate layer (adipocy...

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Abstract

[Problem] A main objective of the present invention is to provide a cell preparation useful for treatment of diseases in bone joints and repairing muscles which have been degenerated or damaged. [Solution] The present invention provides a cell preparation for treatment of diseases in bone joints which comprises a fat cell, and a cell preparation for repairing muscles which comprises a fat cell and a mesodermal stem cell.

Description

technical field [0001] The present invention relates to a cell preparation useful for alleviating pain caused by a disease of a bone joint and treating the disease. In addition, the present invention relates to a cell preparation useful for repairing degenerated or damaged muscles. Background technique [0002] Hyaluronic acid injection, fat cell transplantation, etc. are known as methods for increasing the volume of human soft tissue, and are often used in the fields of cosmetic surgery such as facial wrinkle removal, dimple treatment, breast reconstruction, and plastic surgery. However, although the treatment by hyaluronic acid injection is easy, the injected hyaluronic acid is absorbed in about half a year, so there is a problem that the durability of the effect is lacking. In addition, in the transplantation of adipocytes, the adipocytes may be necrotic or absorbed in the living body after the transplantation. Therefore, there is a disadvantage that reoperation is requ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/12A61L27/00A61P19/02A61P19/04A61P19/08A61P21/00A61P37/00A61K35/35
CPCA61L27/3834A61L2430/06A61L2430/30A61L2430/24A61K35/35A61L27/3852A61L27/3873A61L27/3886A61P19/02A61P19/04A61P19/08A61P21/00A61P37/00A61K35/12A61K35/28
Inventor 佐伯正典
Owner 佐伯正典
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