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Application of 2,5-substituent-1,3,4-oxadiazole sulfone derivatives with function of preventing and controlling bacterial diseases of crops

An oxadiazole sulfone and bacterial technology, which is applied in the application field of 2,5-substituent-1,3,4-oxadiazole sulfone derivatives, can solve the loss of crop bacterial diseases and lack of chemical control Pharmacy, effective control and other problems, to achieve the effect of low production cost, simple preparation process and simple structure

Active Publication Date: 2014-12-24
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the joint influence of climate change, changes in crop varieties and the rapid development of facility agriculture, the losses caused by crop bacterial diseases have increased year by year. Difficult to get effective control in a short time

Method used

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  • Application of 2,5-substituent-1,3,4-oxadiazole sulfone derivatives with function of preventing and controlling bacterial diseases of crops
  • Application of 2,5-substituent-1,3,4-oxadiazole sulfone derivatives with function of preventing and controlling bacterial diseases of crops
  • Application of 2,5-substituent-1,3,4-oxadiazole sulfone derivatives with function of preventing and controlling bacterial diseases of crops

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Determination of the indoor inhibition of citrus canker and cabbage soft rot pathogenic bacteria by some compounds

[0030] experimental method

[0031] The pathogenic bacteria of citrus canker and cabbage soft rot were incubated in NB (beef extract: 3 g, peptone: 5 g, yeast extract: 1 g, glucose: 10 g, agar: 18 g, secondary water: 1 L; with 5 mol / L NaOH solution to adjust the pH to about 7, sterilize at 121 °C for 20 min), streak on the solid medium, and culture at 30 °C until a single colony grows. Pick single colony of citrus canker and cabbage soft rot pathogenic bacteria on NB solid medium to NB liquid medium (beef extract: 3 g, peptone: 5 g, yeast extract: 1 g, glucose: 10 g, secondary water : 1 L; use 5 mol / L NaOH solution to adjust the pH to about 7, sterilize at 121 ℃ for 20 min), and culture on a constant temperature shaker at 28 ℃ and 180 rpm until the logarithmic phase of growth is set aside.

[0032] The synthesized compound and the commercial ...

Embodiment 2

[0038] Example two: highly active compound toxicity regression equation and inhibitory medium concentration (EC 50 ) value determination

[0039] The synthetic compound and the control drug were respectively prepared into 5 corresponding concentrations of toxic NB liquid medium, 5 mL was taken in a test tube, and the OD value of the drug-containing sterile liquid medium was determined with a microplate reader (OD 595 ), adding 40 mu L NB liquid medium containing the pathogenic bacteria of citrus canker or soft rot of cabbage, and then cultured on a constant temperature shaker at 30 °C and 180 rpm for 24-48 h, and measured the OD value of each concentration of the bacterial solution with a microplate reader (OD 595 ). In addition, the OD value of the sterile NB liquid medium containing the control drug and the OD value of each concentration of the bacterial solution after 24 to 48 h were measured, and the OD value caused by the drug itself was corrected. Convert the inhibit...

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Abstract

The invention discloses application of 2,5-substituent-1,3,4-oxadiazole sulfone derivatives with a function of preventing and controlling bacterial diseases of crops. The invention relates to the technical field of chemical engineering and pesticides. A specific technology is as follows: compounds with the type are capable of effectively preventing and controlling citrus bacterial canker and Chinese cabbage soft rot, wherein EC50 values of a compound-2-(4-fluorobenzyl)-5-methylsufonyl-1,3,4-oxadiazole to pathogenic bacteria of the citrus bacterial canker and pathogenic bacteria of the Chinese cabbage soft rot are respectively 1.23 and 29.56 micrograms / ml, and the preventing and controlling effects are best. The 2,5-substituent-1,3,4-oxadiazole sulfone derivatives are applied to the prevention and control of the bacterial disease of the crops, are simple in structure, simple in preparation process, low in production cost, and wide in application prospect. The 2,5-substituent-1,3,4-oxadiazole sulfone derivatives have a following general formula described in the specification.

Description

technical field [0001] The invention relates to the technical fields of chemical engineering and pesticides, and the specific technology is the application of 2,5-substituent-1,3,4-oxadiazole sulfone derivatives capable of preventing and treating bacterial diseases of crops. Background technique [0002] As a large agricultural country, my country plays an extremely important role in ensuring agricultural production. In recent years, with the continuous evolution of my country's agricultural planting structure, climate change, invasion of alien species, and increasing resistance to traditional pesticides, the main crop diseases in my country's agricultural production have shown high frequency, severe damage, and wide range of occurrence. In addition, the increased disease resistance, the unsatisfactory control effect of conventional pesticides, and the excessive residues of agricultural products have caused huge economic losses to agricultural production. Aiming at the curre...

Claims

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Application Information

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IPC IPC(8): A01N43/824A01P1/00
Inventor 宋宝安李培杨松胡德禹薛伟金林红徐维明贺鸣高嫚妮施利杨霞陈学文杨蕾
Owner GUIZHOU UNIV
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