Kit for early diagnosis of nasal pharyngeal cancer (NPC)

An early diagnosis and reagent technology, applied in the field of kits for early diagnosis of NPC, can solve problems such as inability to diagnose nasopharyngeal carcinoma patients, achieve good diagnostic value, simple operation, and reduce missed diagnosis.

Active Publication Date: 2015-02-04
SUN YAT SEN UNIV +1
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Problems solved by technology

[0004] Three early prevention and treatment of nasopharyngeal carcinoma is the key to improve the survival rate. However, in nas

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  • Kit for early diagnosis of nasal pharyngeal cancer (NPC)
  • Kit for early diagnosis of nasal pharyngeal cancer (NPC)
  • Kit for early diagnosis of nasal pharyngeal cancer (NPC)

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Embodiment Construction

[0031] Epstein-Barr virus glycoproteins gH (gp85) and gL exist in the form of heterodimers, the content of which is second only to gp350 in glycoproteins. , host range, tissue tropism, and membrane fusion are closely related. The glycoprotein gH of other types of herpesviruses has been reported many times before to induce immune responses. For example, the varicella-zoster virus glycoprotein complex gH / gL contains a domain structure that can react with the gamma chain of human immunoglobulin IgG; the baculovirus system expresses the recombinant fibrous papilloma-associated herpes virus glycoprotein gH using ELISA. In the diagnosis of fibrous papillomas in sea turtles. However, because the pathogenic mechanism of NPC is not very clear, there is no experimental data showing that the Epstein-Barr virus glycoprotein complex gH / gL is related to the progression of NPC.

[0032] A method for early diagnosis or screening of nasopharyngeal carcinoma, comprising the steps of:

[0033...

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Abstract

The invention discloses a kit for early diagnosis of nasal pharyngeal cancer (NPC). The detection kit has the advantages of being simple to operate, good in repeatability, high in sensitivity and good in specificity; the experimental data proves that gH/gL-immunoglobulin A (IgA) takes OD value of 0.63 as critical value, and the sensitivity and the specificity are respectively 83.7% and 82.3%. The kit provides new detection indexes of the high sensitivity and specificity for the diagnosis of the NPC, thus being beneficial to early screening and diagnosis of the NPC. After being combined with the existing viral capsid antigen (VCA)-IgA detection result, the detection kit has better diagnostic value especially for the VCA-IgA negative patients; the detection kit is complementary with the VCA-IgA, so that missed diagnosis is reduced, and a new way is provided for the early screening and diagnosis of the NPC.

Description

technical field [0001] The invention relates to a diagnostic reagent and an in vitro diagnostic method, in particular to a kit for early diagnosis of NPC. Background technique [0002] Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in my country. It is more common in Guangdong, Guangxi, Hunan, Fujian, Jiangxi and other provinces in southern my country. The incidence rate of men is 2 to 3 times that of women. The age distribution of case reports in my country is 3 to 90 years old, but 30 to 50 years old is the high incidence age area. [0003] Patients with nasopharyngeal carcinoma not only have high titers of anti-Epstein-Barr virus antibodies, but also their antibody levels change with the development of the disease. Some specific serum markers have been widely used in population screening and early diagnosis in areas with a high incidence of nasopharyngeal carcinoma . As early as the 1970s, the detection of EBV capsid antigen (VCA) and early ant...

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Application Information

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IPC IPC(8): G01N33/574
CPCG01N33/57407
Inventor 曾木圣黄晓明李瑞辰杜勇张星韩萍钟茜李满枝刘万里
Owner SUN YAT SEN UNIV
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