Epsilon-polylysine-vitamin E succinate amide compound, and preparation method and application thereof

A technology of succinic acid ester amide and polylysine, applied in the application, food science, food preservation and other directions, can solve the problem of poor lipid solubility of ε-polylysine, achieve easy promotion, slow down product oxidation, expand Application-wide effects

Active Publication Date: 2015-02-18
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] The invention provides an ε-polylysine-vitamin E succinate amide compound and its preparation method and application. The amide compound not only has high

Method used

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  • Epsilon-polylysine-vitamin E succinate amide compound, and preparation method and application thereof
  • Epsilon-polylysine-vitamin E succinate amide compound, and preparation method and application thereof
  • Epsilon-polylysine-vitamin E succinate amide compound, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] In a two-neck round-bottomed flask, nitrogen was added, 2.862gε-polylysine (ε-PL), 3.600g tocopheryl succinate (TOS), 10mL anhydrous dimethylformamide (DMF), 46.5uL were added Catalyst NN diisopropylcarbodicarboximide (DIC), stirred and reacted at 40°C for 18h. After the reaction is completed, chromatographic separation, dialysis purification, vacuum rotary evaporation, and freeze drying are carried out to obtain ε-PL-TOS Amide complex.

Embodiment 2

[0043] In a two-necked round-bottom flask, nitrogen was added, 1.208gε-polylysine (ε-PL), 0.955g tocopheryl succinate (TOS), 5mL anhydrous dimethylformamide (DMF), 22.5uL were added Catalyst NN diisopropylcarbodicarboximide (DIC), stirred and reacted at 40°C for 20 hours. After the reaction is completed, chromatographic separation, dialysis purification, vacuum rotary evaporation, and freeze drying are carried out to obtain ε-PL-TOS Amide complex.

Embodiment 3

[0045] In a two-neck round-bottomed flask, nitrogen was added, 2.035gε-polylysine (ε-PL), 2.275g tocopherol succinate (TOS), 7.5mL anhydrous dimethylformamide (DMF), 34.5 uL catalyst NN diisopropylcarbodicarboximide (DIC), stirred, and reacted at 35°C for 20 hours. After the reaction is completed, chromatographic separation, dialysis purification, vacuum rotary evaporation, and freeze drying are carried out to obtain ε-PL- TOS amide complex.

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Abstract

The invention discloses an Epsilon-polylysine-vitamin E succinate amide compound, and a preparation method and application thereof. The amide compound has the structure shown as in formula (I), and is obtained by a nucleophilic substitution reaction on Epsilon-polylysine and -vitamin E succinate under the catalysis of N-N dilauryl hydroge dicarboximide. The amide compound has high bacteriostatic ability and emulsibility, and solves the problem of low lipid solubility of Epsilon-polylysine in the prior art.

Description

Technical field [0001] The invention relates to the technical field of biological food, in particular to an epsilon-polylysine-vitamin E succinate amide complex and a preparation method and application thereof. Background technique [0002] ε-polylysine (ε-PL) was first discovered in the culture medium of Streptomyces albicans by Japanese scholar Shima et al. It is used as a natural preservative due to its good water solubility, broad-spectrum bacteriostasis and degradable into easily absorbed lysine in the body, and was approved by the FDA as a safe food preservation agent in October 2003. [0003] ε-PL is light yellow powder with strong hygroscopicity and slightly bitter taste. ε-PL is a linear polymer of lysine, which is not affected by pH changes and is thermally stable (120°C, 20min). It can be used in combination with hydrochloric acid, citric acid, malic acid, glycine and higher fatty acid glycerides. , Has a synergistic effect. ε-PL is a microbial food preservative with ...

Claims

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Application Information

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IPC IPC(8): C08G69/48A23L3/3544
Inventor 何荣军王宇光赵瑞娜施俊妃孙培龙
Owner ZHEJIANG UNIV OF TECH
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