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Epsilon-polylysine-vitamin E succinate amide compound, and preparation method and application thereof

A technology of succinic acid ester amide and polylysine, applied in the application, food science, food preservation and other directions, can solve the problem of poor lipid solubility of ε-polylysine, achieve easy promotion, slow down product oxidation, expand Application-wide effects

Active Publication Date: 2015-02-18
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The invention provides an ε-polylysine-vitamin E succinate amide compound and its preparation method and application. The amide compound not only has high antibacterial ability, but also has emulsifying properties, which solves the existing problems The problem of poor fat solubility of ε-polylysine in technology

Method used

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  • Epsilon-polylysine-vitamin E succinate amide compound, and preparation method and application thereof
  • Epsilon-polylysine-vitamin E succinate amide compound, and preparation method and application thereof
  • Epsilon-polylysine-vitamin E succinate amide compound, and preparation method and application thereof

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Effect test

Embodiment 1

[0041] In a two-neck round-bottomed flask, nitrogen was added, 2.862gε-polylysine (ε-PL), 3.600g tocopheryl succinate (TOS), 10mL anhydrous dimethylformamide (DMF), 46.5uL were added Catalyst NN diisopropylcarbodicarboximide (DIC), stirred and reacted at 40°C for 18h. After the reaction is completed, chromatographic separation, dialysis purification, vacuum rotary evaporation, and freeze drying are carried out to obtain ε-PL-TOS Amide complex.

Embodiment 2

[0043] In a two-necked round-bottom flask, nitrogen was added, 1.208gε-polylysine (ε-PL), 0.955g tocopheryl succinate (TOS), 5mL anhydrous dimethylformamide (DMF), 22.5uL were added Catalyst NN diisopropylcarbodicarboximide (DIC), stirred and reacted at 40°C for 20 hours. After the reaction is completed, chromatographic separation, dialysis purification, vacuum rotary evaporation, and freeze drying are carried out to obtain ε-PL-TOS Amide complex.

Embodiment 3

[0045] In a two-neck round-bottomed flask, nitrogen was added, 2.035gε-polylysine (ε-PL), 2.275g tocopherol succinate (TOS), 7.5mL anhydrous dimethylformamide (DMF), 34.5 uL catalyst NN diisopropylcarbodicarboximide (DIC), stirred, and reacted at 35°C for 20 hours. After the reaction is completed, chromatographic separation, dialysis purification, vacuum rotary evaporation, and freeze drying are carried out to obtain ε-PL- TOS amide complex.

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Abstract

The invention discloses an Epsilon-polylysine-vitamin E succinate amide compound, and a preparation method and application thereof. The amide compound has the structure shown as in formula (I), and is obtained by a nucleophilic substitution reaction on Epsilon-polylysine and -vitamin E succinate under the catalysis of N-N dilauryl hydroge dicarboximide. The amide compound has high bacteriostatic ability and emulsibility, and solves the problem of low lipid solubility of Epsilon-polylysine in the prior art.

Description

Technical field [0001] The invention relates to the technical field of biological food, in particular to an epsilon-polylysine-vitamin E succinate amide complex and a preparation method and application thereof. Background technique [0002] ε-polylysine (ε-PL) was first discovered in the culture medium of Streptomyces albicans by Japanese scholar Shima et al. It is used as a natural preservative due to its good water solubility, broad-spectrum bacteriostasis and degradable into easily absorbed lysine in the body, and was approved by the FDA as a safe food preservation agent in October 2003. [0003] ε-PL is light yellow powder with strong hygroscopicity and slightly bitter taste. ε-PL is a linear polymer of lysine, which is not affected by pH changes and is thermally stable (120°C, 20min). It can be used in combination with hydrochloric acid, citric acid, malic acid, glycine and higher fatty acid glycerides. , Has a synergistic effect. ε-PL is a microbial food preservative with ...

Claims

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Application Information

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IPC IPC(8): C08G69/48A23L3/3544
Inventor 何荣军王宇光赵瑞娜施俊妃孙培龙
Owner ZHEJIANG UNIV OF TECH
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