ε-polylysine-vitamin e succinate amide complex and its preparation method and application

A technology of succinate amide and polylysine, applied in application, food science, food preservation, etc., can solve the problem of poor fat solubility of ε-polylysine, and achieve easy promotion, easy control, and antibacterial broad spectrum effect

Active Publication Date: 2016-06-29
ZHEJIANG UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] The invention provides an ε-polylysine-vitamin E succinate amide compound and its preparation method and application. The amide compound not only has high antibacterial ability, but also has emulsifying properties, which solves the existing problems The problem of poor fat solubility of ε-polylysine in technology

Method used

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  • ε-polylysine-vitamin e succinate amide complex and its preparation method and application
  • ε-polylysine-vitamin e succinate amide complex and its preparation method and application
  • ε-polylysine-vitamin e succinate amide complex and its preparation method and application

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Embodiment 1

[0042]In a two-necked round-bottom flask, nitrogen gas was added, 2.862g ε-polylysine (ε-PL), 3.600g tocopheryl succinate (TOS), 10mL anhydrous dimethylformamide (DMF), 46.5uL Catalyst N,N'-diisopropylcarbodiimide (DIC), stirred, and reacted at 40°C for 18 hours. After the reaction was completed, ε-PL was obtained through chromatographic separation, dialysis purification, vacuum rotary evaporation, and freeze-drying -TOS amide complex.

Embodiment 2

[0044] In a two-neck round-bottom flask, nitrogen gas was added, 1.208g ε-polylysine (ε-PL), 0.955g tocopheryl succinate (TOS), 5mL anhydrous dimethylformamide (DMF), 22.5uL Catalyst N,N'-diisopropylcarbodiimide (DIC), stirred, and reacted at 40°C for 20 hours. After the reaction was completed, ε-PL was obtained through chromatographic separation, dialysis purification, vacuum rotary evaporation, and freeze-drying -TOS amide complex.

Embodiment 3

[0046] In a two-necked round-bottomed flask, nitrogen gas was added, 2.035g ε-polylysine (ε-PL), 2.275g tocopheryl succinate (TOS), 7.5mL anhydrous dimethylformamide (DMF), 34.5 uL of catalyst N,N'-diisopropylcarbodiimide (DIC), stirred, and reacted at 35°C for 20 hours. After the reaction was completed, ε- PL-TOS amide complex.

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Abstract

The invention discloses an Epsilon-polylysine-vitamin E succinate amide compound, and a preparation method and application thereof. The amide compound has the structure shown as in formula (I), and is obtained by a nucleophilic substitution reaction on Epsilon-polylysine and -vitamin E succinate under the catalysis of N-N dilauryl hydroge dicarboximide. The amide compound has high bacteriostatic ability and emulsibility, and solves the problem of low lipid solubility of Epsilon-polylysine in the prior art.

Description

technical field [0001] The invention relates to the technical field of biological food, in particular to an ε-polylysine-vitamin E succinate amide complex and its preparation method and application. Background technique [0002] ε-polylysine (ε-polylysine, ε-PL) was first discovered by Japanese scholar Shima et al. in the culture medium of Streptomyces albicans. It is used as a natural preservative because of its good water solubility, broad-spectrum antibacterial properties, and the ability to degrade into easily absorbed lysine in the body. It was approved by the FDA as a safe food preservative in October 2003. [0003] ε-PL is light yellow powder with strong hygroscopicity and slightly bitter taste. ε-PL is a linear polymer of lysine, which is not affected by the change of pH value and is stable to heat (120°C, 20min). After being used in combination with hydrochloric acid, citric acid, malic acid, glycine and higher fatty acid glycerides , has a synergistic effect. ε-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G69/48A23L3/3544
Inventor 何荣军王宇光赵瑞娜施俊妃孙培龙
Owner ZHEJIANG UNIV OF TECH
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