Sulfadoxine production process

Abstract

The invention discloses a sulfadoxine production process. The sulfadoxine production process includes the steps: 1) enabling reaction of methyl methoxyacetate and diethyl oxalate to generate 3-methoxy-2-ethyl oxo-succinate formate; 2) in existence of sodium methoxide, enabling 2-methoxy-ethyl malonate formate to react with formamide, adding water, recovering aqueous methanol, spinning, discharging and drying to obtain a ring compound; 3) enabling the ring compound and phosphoryl chloride to flow back at 65 DEG C, and performing heat reaction for 3 hours to generate 4,6-dichloro-5-methoxy pyrimidine; 4) subjecting the 4,6-dichloro-5-methoxy pyrimidine and aminophenol sulfamide sodium to condensation reaction to generate 4-(sulfanilamide)-5-methoxy-6-chloropyrimidine; 5) putting the 4-(sulfanilamide)-5-methoxy-6-chloropyrimidin into a reaction kettle, adding methanol and solid sodium hydroxide, slowly heating to 60 DEG C, and performing heat reaction for 2.5 hours to obtain a finished sulfadoxine product. The sulfadoxine production process has the advantages of high sulfadoxine production yield.

Description

technical field

[0001] The invention relates to a production process of sulfonamide. Background technique

[0002] The existing sulfonamide production process has a low yield. Contents of the invention

[0003] The purpose of the present invention is to provide a kind of production technology of sulfonamide, which has a high yield of sulfonamide.

[0004] For achieving the above object, technical scheme of the present invention is to design a kind of production technique of sulfonamide, comprising the steps:

[0005] 1) In the presence of solid sodium ethylate, react 15 parts by mass of methyl methoxyacetate with 32.3 parts by mass of diethyl oxalate to generate methylethyl 3-methoxy-2-oxobutanedioate, and further remove Carbonyl, and then recover the low boilers by decompression and fractionation in a fractionating tower. After the low boilers are separated, directly cool the remaining reaction liquid without passing through the fractionating tower to obtain 2-methoxy-m...