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Pharmaceutical composition and preparation thereof for treating stroke and sequelae thereof

A sequelae, traditional Chinese medicine technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of complex ingredients, unsatisfactory, large dosage, etc., to achieve high content, increased efficacy, and convenient quality. control effect

Active Publication Date: 2015-03-18
陈震
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Modern traditional Chinese medicine basically has three methods for the treatment of cerebral infarction, dizziness, headache and other stroke and sequelae of stroke. One tends to follow the traditional compound prescription for treatment, such as Xuefu Zhuyu Decoction, Taoren Siwu Decoction, Huatuo Zaizao Pills, etc. , these traditional compound medicines have many flavors, complex ingredients, and large doses, which cannot meet the needs of modern medicine; the second type uses the theory of western medicine and western medicine, or thrombolysis, or blood pressure reduction, or anticoagulation, or pain relief, etc.

Method used

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  • Pharmaceutical composition and preparation thereof for treating stroke and sequelae thereof
  • Pharmaceutical composition and preparation thereof for treating stroke and sequelae thereof
  • Pharmaceutical composition and preparation thereof for treating stroke and sequelae thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: the preparation of ginkgo gastrodia elata injection (ampule)

[0028] ① Clean and dry 100kg of ginkgo biloba raw medicinal material, crush it, extract twice with 800kg of 70% ethanol under reflux, each time for 3 hours, filter, concentrate the extract to a relative density of 1.10, and put the non-substituted porous resin on the concentrate Column, eluted with water until colorless, then eluted with 90% ethanol, concentrated the eluate to no alcohol, extracted with ethyl acetate, separated the ethyl acetate liquid, concentrated and applied to an acidic alumina column, and eluted with 95% ethanol , the eluent was concentrated and crystallized, and recrystallized from 95% ethanol to obtain 100g ginkgolide B, and the HPLC measured content was more than 95%;

[0029] ② Dissolve ginkgolide B in 500mL PEG400, add 500mL medicinal ethanol until dissolved;

[0030] ③Add 1500g gastrodin into the medicinal solution containing ginkgolide B, and dissolve it by ultraso...

Embodiment 2

[0037] Embodiment 2: the preparation of Ginkgo Tianma injection (vial)

[0038] ① Clean and dry 100kg of ginkgo biloba raw medicinal material, crush it, extract twice with 800kg of 70% ethanol under reflux, each time for 3 hours, filter, concentrate the extract to a relative density of 1.10, and put the non-substituted porous resin on the concentrate Column, eluted with water until colorless, then eluted with 90% ethanol, concentrated the eluate to no alcohol, extracted with ethyl acetate, separated the ethyl acetate liquid, concentrated it, put it on an acidic alumina column, and washed it with 95% 7 alcohol The eluate was concentrated and crystallized, and 100g ginkgolide B was obtained by recrystallization from 95% alcohol, and the content measured by HPLC was more than 95%;

[0039] ② Dissolve ginkgolide B in 500mL PEG400, add 500mL medicinal ethanol until dissolved;

[0040] ③Add 1500g gastrodin into the medicinal liquid containing ginkgolide B, and dissolve it by ultras...

Embodiment 3

[0047] Embodiment 3: the preparation of ginkgo gastrodia elata powder injection

[0048] ① Clean and dry 50kg of ginkgo biloba raw medicinal materials, crush them, extract twice with 400kg of 70% ethanol under reflux, each time for 3 hours, filter, concentrate the extract to a relative density of 1.10, and put the non-substituted porous resin on the concentrate Column, eluted with water until colorless, then eluted with 90% ethanol, concentrated the eluate to no alcohol, extracted with ethyl acetate, separated the ethyl acetate liquid, concentrated and applied to an acidic alumina column, and eluted with 95% ethanol , the eluent was concentrated and crystallized, and recrystallized from 95% ethanol to obtain 50g ginkgolide B, and the HPLC measured content was more than 95%;

[0049] ② Dissolve ginkgolide B in 250mL PEG400, add 500mL medicinal ethanol until dissolved;

[0050] ③Add 750g of gastrodin into the medicinal solution containing ginkgolide B, and dissolve it by ultras...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a preparation process for a pharmaceutical composition and the injection thereof for treating stroke and sequelae thereof. The pharmaceutical composition contains 10-100 parts of bilobalide B and 100-1000 parts of gastrodin. The invention overcomes shortages in the prior art, and provides a preparation method for a traditional Chinese medicine injection formed by combining bilobalide B with gastrodin, and a treatment medicine for cerebrovascular diseases of stroke, stroke sequelae, vascular dementia, dizziness, migraine and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a pharmaceutical composition for resisting apoplexy and its sequelae and a preparation process for an injection. Background technique [0002] Stroke, also known as cerebrovascular accident or cerebral apoplexy, is a type of disease with sudden coma, unconsciousness, accompanied by crooked mouth and eyes, dysphasia, hemiplegia or sudden hemiplegia without fainting as the main symptoms. It is generally divided into two categories: hemorrhagic stroke such as cerebral hemorrhage, subarachnoid hemorrhage and ischemic stroke such as cerebral artery thrombosis and cerebral embolism. This disease mainly occurs in patients over 40 years old. Patients with original atherosclerosis, hypertension, and cerebrovascular malformation are induced by factors such as mood swings, worry, anger, and excessive mental stress, resulting in blood vessel rupt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P25/28A61P25/06A61P25/00A61K31/365
Inventor 陈震
Owner 陈震
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