Cefquinome sulfate breast injection for dairy cow in lactation period and preparation method thereof

A technology of cefquinoxime sulfate and breast injection, which can be applied in the directions of medical preparations containing active ingredients, pharmaceutical formulas, emulsion delivery, etc. Convenience, quickness, and uniform formulation

Active Publication Date: 2015-04-29
FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing cefquinome sulfate injection and powder injection are mainly administered through intramuscular injection, which is difficult to reach the inside of the breast, and is not as effective as topical administration of the breast

Method used

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  • Cefquinome sulfate breast injection for dairy cow in lactation period and preparation method thereof
  • Cefquinome sulfate breast injection for dairy cow in lactation period and preparation method thereof
  • Cefquinome sulfate breast injection for dairy cow in lactation period and preparation method thereof

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preparation example Construction

[0028] Cefquinome sulfate breast injection provided by the invention is a uniformly distributed preparation, and the specific preparation method comprises the following steps:

[0029] A. Let the vegetable oil (such as neutral soybean oil) cool after filtering and heat sterilization;

[0030] B takes an appropriate amount of pretreated vegetable oil, and adds 0008-008g of glyceryl monostearate;

[0031] C. Heat at 60-80°C for 15-30 minutes, wait for the glyceryl stearate to melt, stir evenly, cool to about 40°C, add 0.008-0.08g of suspending agent (such as Span 80), 0.05-0.15 g (calculated as cefquinome) of cefquinome sulfate (particle size 5-10 μm), and then add vegetable oil to a total of 8.0 g;

[0032] D. grind evenly, make cefquinome sulfate breast injection;

[0033] F. Put the medicine into the injection tube, seal it, sterilize it, inspect it with light, and pack it.

[0034] In the following examples, the detection method of the sedimentation particle size of the b...

Embodiment 1

[0037] Embodiment 1, the prescription screening of cefquinome sulfate breast injection

[0038] 1. Screening of the content of glyceryl monostearate in the formula (note: glyceryl monostearate in the table is referred to as glycerol)

[0039] Table 1

[0040]

[0041] The preparation method is as follows:

[0042] 1) Superfinely pulverize the sterile cefquinome sulfate powder to obtain sterile micropowder of cefquinome sulfate (particle size: 5-10 μm);

[0043] 2) After the soybean oil is filtered and heat sterilized (sterilized at 150°C for 3 hours), put it at room temperature for later use;

[0044] 3) Take an appropriate amount of pretreated soybean oil, add glyceryl stearate and suspending agent Span 80; heat and stir (heating at 80°C for 15 minutes), after the glyceryl stearate melts, add cefquinone sulfate Oxime;

[0045] 5) Grind evenly in a sterile colloid mill to prepare cefquinome sulfate breast injection.

[0046] As can be seen from the results in Table 1, ...

Embodiment 2

[0052] Embodiment 2, preparation cefquinome sulfate breast injection (lactating period)

[0053]

[0054] The preparation method is as follows:

[0055] 1) Superfinely pulverize the sterile cefquinoxime sulfate powder to obtain the sterile fine powder of cefquinoxime sulfate with a particle size of 5-10 μm;

[0056] 2) After the soybean oil is filtered and heat sterilized (sterilized at 150°C for 3 hours), put it at room temperature for later use;

[0057] 3) Take an appropriate amount of pretreated soybean oil (40%-60% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (heating at 80°C for 15 minutes), wait for glyceryl monostearate Melt the ester, stir evenly, cool to 40°C, add Span 80, cefquinome sulfate, and add soybean oil to the full amount;

[0058]4) Grind evenly in a sterile colloid mill to prepare cefquinome sulfate breast injection.

[0059] The properties of the obtained cefquinome sulfate breast injection (lactating period) are off...

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Abstract

The invention discloses a cefquinome sulfate breast injection for dairy cow in the lactation period and a preparation method thereof. The cefquinome sulfate breast injection is prepared from the following raw and auxiliary materials: 0.05-0.15g of cefquinome sulfate (based on cefquinome), 0.008-0.08g of glyceryl monostearate, 0.008-0.08g of a suspending agent and the balance of vegetable oil which is added until the total weight is 8.0g. The preparation method comprises the following steps: adding glyceryl monostearate into a proper amount of pre-treated vegetable oil, heating and melting; then, adding the suspending agent and cefquinome sulfate, and adding the vegetable oil to the total amount; and uniformly grinding. The breast injection has the advantages of low drug release speed, high bioavailability and small irritation to local tissues; each lactation region of each dairy cow is independently administrated, so that cross infection is avoided; the injection is injected through breast and is convenient to use, so that animal stress reaction caused by parenteral administration can be avoided, and convenience is brought to clinical administration; the injection has a remarkable curative effect and extremely high popularization value.

Description

technical field [0001] The invention relates to a cefquinome sulfate breast injection (lactating period) and a preparation method thereof. Background technique [0002] In recent years, with the continuous adjustment of the breeding structure, my country's dairy farming industry has made great progress in terms of scale. However, the incidence of dairy cow mastitis in production is very high. It is caused by Staphylococcus aureus, Streptococcus, Escherichia coli, etc. It is a frequently-occurring and intractable disease caused by the main pathogenic bacteria. In clinical practice, it is seen that the sick cows are depressed, their body temperature rises, and their appetite is lost; their lactation decreases, their milk is thin, and they feel fever and redness when touched. The milk contains flocs Or milk clot etc., cause milk yield and milk quality to reduce, have a strong impact on the healthy development of dairy industry, this disease not only causes great economic loss to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/546A61P15/14A61P31/04
Inventor 李秀波刘义明闫星张道康赵蕾蕾刘茂林
Owner FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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