Quality control sample for detecting breast cancer and preparation method of quality control sample

A quality control product, breast cancer technology, applied in the fields of clinical laboratory, pathology and biology, can solve the problems of inability to specifically reflect HER2 false positives, limited sources of quality control products, poor consistency, etc. Simple operation, repeatable and consistent results
CN104569397AActive Publication Date: 2015-04-29BEIJING HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING HOSPITAL
Publication Date
2015-04-29

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Abstract

The invention discloses a quality control sample for detecting breast cancer and a preparation method of the quality control sample, particularly relates to a quality control material for HER2 gene amplification FISH detection and a preparation method of the quality control material, and belongs to the technical fields of clinical laboratory medicine, pathology and biotechnology. The quality control sample for detecting the breast cancer is a paraffin-embedded specimen slice prepared by a cultivated breast cancer cell line. The quality control sample has the advantages that the quality control sample prepared by the breast cancer cell line cultured in vitro can be used as substitute goods of the quality control sample for fabricating real tissue samples, and is high in sample capacity and high in repeatability; and detection of different HER2 gene levels can be finished by selecting difference cell lines. The quality control sample is simple and convenient in preparation method, and easy to store, can be put into volume production, and can be applied to internal quality control and external quality assessment.
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Description

technical field

[0001] The invention relates to a breast cancer detection quality control substance and a preparation method thereof, in particular to a quality control substance for HER2 gene amplification FISH detection and a preparation method thereof, belonging to the fields of clinical laboratory science, pathology and biotechnology. Background technique

[0002] Breast cancer is one of the most common malignant tumors in women, and its incidence is increasing year by year. Proto-oncogene HER2 (human epidermal growth factor receptor 2 gene) is one of the hotspots of current research. According to data, about 20-30% of invasive ductal carcinomas of breast cancer have overexpression of HER2 gene. A large number of studies have confirmed that HER2 gene amplification is not only closely related to the occurrence, development and prognosis of breast cancer, but also crucial to the selection of drug treatment options.

[0003] HER2-positive breast cancer has poor response t...

Claims

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