Oil-in-water type menthol ointment and preparation method thereof

An oil-in-water type, peppermint ointment technology is applied in the directions of ointment delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc. Children use and other problems to achieve the effect of inhibiting the production of inflammatory mediators, promoting epithelial growth, and inhibiting lipoxygenase and cyclooxygenase

Active Publication Date: 2015-05-06
GUANGDONG SHUNFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, since the peppermint paste formula contains volatile components such as camphor and menthol, when it is prepared into an oil-in-water type peppermint paste, problems such as discoloration, thinning, and oil separation of the paste are likely to occur
Camphor and menthol belong to terpenes and are volatile. In the oil-in-water cream system, they are easy to gather due to the increase of ambient temperature (such as in summer with high temperature), so that the oil droplets gradually increase, and finally Destroying the stability of the emulsification system, making the paste thinner and oil separation; at the same time, the accumulation of volatile oil makes the easily oxidized components unable to be effectively protected by antioxidants, and oxidative discoloration is more likely to occur
Because it is difficult to solve the stability problem of oil-in-water cream system by using traditional emulsifier and emulsification process, the development of oil-in-water mint cream is limited
[0005] Furthermore, traditional peppermint paste contains a large amount of camphor, menthol and methyl salicylate, wherein the content of camphor is about 8-15%, the content of menthol is about 1-5%, and the content of methyl salicylate It is about 0.3-0.5%. It is more irritating to the skin and has sensitization. It is not suitable for long-term use, especially for infants and young children.

Method used

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  • Oil-in-water type menthol ointment and preparation method thereof
  • Oil-in-water type menthol ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of the oil-in-water peppermint cream of the present invention

[0035] According to the formula shown in Table 1 below, weigh each component separately.

[0036] Table 1

[0037] Ingredients

Dosage

Glycerin

20g

Camphor

1.5g

Menthol

1.5g

Eucalyptus blue oil

1.0g

Ammonium Glycyrrhizinate

0.6g

Vitamin E

1.2g

Allantoin

0.3g

Citronella oil

0.8g

grape seed oil

4.5g

Beeswax

1.2g

Cetearyl alcohol

5.5g

Caprylic / Capric Triglyceride

4.0g

Polydimethylsiloxane

3.5g

Glyceryl stearate

2.0g

Ethyl paraben

0.3g

Phenoxyethanol

0.3g

Methyl isothiazolinone

0.008g

Butylated hydroxytoluene

0.04g

[0038] Laureth-20

2.0g

Ammonium polyacrylate / C13-16 isoparaffin / Laureth-25

4.0g

purified water

Add water to 100g

[0039] Take ammonium glycyrrhizinate, add an appropriate amount of glycerin, stir and suspend it evenly, then add the same amount of purified water as the glycerin, stir and heat to 55°C to dissolve to obtain a lic...

Embodiment 2

[0044] Example 2: Performance test of the oil-in-water peppermint cream of the present invention

[0045] 1. Stability test

[0046] 1. 160℃ high temperature influencing factors test

[0047] Test method: Put the oil-in-water peppermint ointment prepared in Example 1 in a 60°C thermostat, and investigate its pH value, uniformity, discoloration and whether there is water separation at 60°C for 3 days, 7 days, and 14 days , Oil separation, stratification phenomenon, and compared with the sample at room temperature 0 days.

[0048] Test result: The oil-in-water peppermint cream of the present invention has no water, oil, or delamination phenomena under the condition of 60°C for 14 days, and has good uniformity. Compared with the samples at room temperature for 0 days, the pH value and discoloration are no Obvious difference.

[0049] The test results show that the oil-in-water peppermint ointment of the present invention can withstand a certain high temperature and has good stability.

[...

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PUM

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Abstract

The invention discloses oil-in-water type menthol ointment and a preparation method thereof. The oil-in-water type menthol ointment comprises glycerol, camphor, menthol, eucalyptus globulus leaf oil, a liquorice extract, vitamin E, allantoin, citronella oil and the like. The oil-in-water type menthol ointment has the effects of cooling and refreshing, diminishing inflammation, relieving itching and repelling mosquitoes, and has the advantages of being high in stability, low in irritation and small in oily feeling.

Description

Technical field [0001] The invention relates to a peppermint ointment and a preparation method thereof, in particular to an oil-in-water type peppermint ointment and a preparation method thereof. Background technique [0002] The traditional peppermint ointment is an ointment type preparation with camphor and menthol as the main ingredients and added with medicinal ingredients such as methyl salicylate, which mainly plays a role in cooling and relieving itching. [0003] The traditional peppermint ointment uses an ointment-type base, which has a heavy greasy feel when used. Too much oil on the skin will produce a sticky and uncomfortable skin feel, which is not convenient for daily use. In addition, the peppermint ointment of the ointment type matrix is ​​more sensitive to changes in ambient temperature, and oil separation is likely to occur when the temperature is high in summer, which seriously affects the use and efficacy of the peppermint ointment; moreover, it is difficult to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K47/34A61K9/06A61P17/04A61K36/534
Inventor 郭丽娟王北明梁勇坤张超钟敏贤龚俊瑞
Owner GUANGDONG SHUNFENG PHARMA
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