Method for dissolving ambroxol hydrochloride raw materials

Abstract

The invention discloses a method for dissolving ambroxol hydrochloride raw materials. The method comprises the following steps: A, taking 25L of water for injection, adding auxiliary materials such as 3.0kg of citric acid, 2.4kg of disodium hydrogen phosphate and 1.5kg of sodium hydrogen sulfite, and adding 0.9kg of ambroxol hydrochloride after dissolving, thereby obtaining the concentrated liquor of ambroxol hydrochloride for later use; B, adding the concentrated liquor of ambroxol hydrochloride into a dilution tank, adding water for injection to reach 3000L, and stirring for 10 minutes, thereby obtaining an initial solution of ambroxol hydrochloride; and C, performing circulating filtration by virtue of a titanium stick filter, and preparing the ambroxol hydrochloride solution at the temperature of 50-60 DEG C by virtue of a first pleated filter cartridge filter and a second pleated filter cartridge filter. According to the method disclosed by the invention, ambroxol hydrochloride can be completely dissolved in water, the uniformity is high, the oxidative degradation problem of ambroxol hydrochloride can be effectively solved, and the ambroxol hydrochloride solution with good dissolving property and difficulty in denaturation is prepared.

Description

technical field [0001] The invention relates to the field of preparations, in particular to a method for dissolving ambroxol hydrochloride raw materials. Background technique [0002] The raw material of ambroxol hydrochloride is the active ingredient of ambroxol hydrochloride glucose injection, which can promote the elimination of viscous secretions in the respiratory tract and reduce the retention of mucus, thus significantly promoting expectoration. It is suitable for patients with abnormal sputum secretion and excretion. Acute and chronic respiratory diseases with poor sputum function. Yet the solubility of ambroxol hydrochloride is little, and it is extremely difficult to dissolve in water, therefore can affect the homogeneity of this medicinal liquid, and ambroxol hydrochloride is easily oxidized and degraded in addition, is unfavorable for long-term preservation. [0003] Therefore, the prior art still needs to be improved and developed. Contents of the invention ...

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Problems solved by technology

[0004] In view of above-mentioned deficiencies in the prior art, the object of the present invention is to provide a kind of dissolving method of ambroxol hydrochloride raw material, aims to solve the problem that ambroxol hydrochloride raw material is insoluble in water and easily oxidatively degraded in the prior art

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